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| 环氧氯丙烷染毒大鼠肝和脑干组织中cAMP,cGMP和CaM含量的变化 | |
| 引用本文： | 尹占莉 孙克任. 环氧氯丙烷染毒大鼠肝和脑干组织中cAMP,cGMP和CaM含量的变化[J]. 毒理学杂志, 1992, 6(4): 270-272 |
| 作者姓名： | 尹占莉 孙克任 |
| 作者单位： | 青岛医学院卫生学教研室，山东医科大学毒理教研室 青岛 266021，济南 250012 |
| 摘 要： | 应用放免技术和钙调泰(CaM)的酶联免疫测试法(ELISA)测定了大鼠EPI染毒后肝和脑干组织中cAMP、cGMP及CaM的含量变化。结果表明,随着染毒剂量的增加肝组织中cAMP、cGMP和CaM含量均呈上升趋势,其中,cAMP和CaM上升一致,cAMP/cGMP值升高;脑干组织中cAMP含量增加,cGMP和CaM无明显变化。本文还讨论了EPI染毒后脑干组织中cAMP、cGMP和DaM含量变化的可能机制和意义。 |
| 关 键 词： | 环氧氯丙烷 环磷酸腺苷 环磷酸鸟苷 |
Content Changes of cAMP, cGMP and CaM in The Liver and Brainstem of Rat after Giving Epichlorohydrin |
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| Yin Zhan-li,et al.. Content Changes of cAMP, cGMP and CaM in The Liver and Brainstem of Rat after Giving Epichlorohydrin[J]. Journal of Toxicology, 1992, 6(4): 270-272 | |
| Authors: | Yin Zhan-li et al. |
| Abstract: | Content changes of cAMP, cGMP and CaM in the liver and brainstem of rat after giving Epichlorohydrin ( EPI ) were determined by RIA and ELISA. The results showed that the levels of cAMP and CaM of the liver were raised with the increase of the dose of EPI. the cAMP/cGMP ratio was increased. In brainstem the levels of cAMP got higher,but no apparent level changes of cGMP and CaM were seen. The results mentioned above suggested that by indirect effect on liver cells ( EPI might ) activate adenylate cyclase and increase the formation of CaM complex, and cause an increase in cAMP and CaM content, and make blood sugar raise. In this Paper we also discuss the probable mechanism and significance of the change in levels of cAMP, cGMP and CaM in the brainstem after giving EPI. |
| Keywords: | Epichlorohydrin cAMP cGMP Calmodulin Liver Brainstem. |
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