Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD) |
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| Authors: | Christopher L Edwards Renee Dunn Raynor Miriam Feliu Camela McDougald Stephanie Johnson Donald Schmechel Mary Wood Gary G Bennett Patrick Saurona Melanie Bonner Chante&#x; Wellington Laura M DeCastro Elaine Whitworth Mary Abrams Patrick Logue Lekisha Edwards Salutario Martinez and Keith E Whitfield |
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| Institution: | Christopher L Edwards, Renee Dunn Raynor, Miriam Feliu, Camela McDougald, Stephanie Johnson, Donald Schmechel, Mary Wood, Gary G Bennett, Patrick Saurona, Melanie Bonner, Chante’ Wellington, Laura M DeCastro, Elaine Whitworth, Mary Abrams, Patrick Logue, Lekisha Edwards, Salutario Martinez, and Keith E Whitfield |
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| Abstract: | Traditionally, neuropsychological deficits due to Sickle Cell Disease (SCD) have been understudied in adults. We have begun to suspect, however, that symptomatic and asymptomatic Cerebrovascular Events (CVE) may account for an alarming number of deficits in this population. In the current brief review, we critically evaluated the pediatric and adult literatures on the neurocognitive effects of SCD. We highlighted the studies that have been published on this topic and posit that early detection of CVE via neurocognitive testing, neuropsychiatric evaluations, and neuroimaging may significantly reduce adult cognitive and functional morbidities. |
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