Inhibition of angiogenesis by extracellular protein kinase A |
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| Authors: | Maria Szkudlarek Rual M. Bosio Qiong Wu Khew-Voon Chin |
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| Affiliation: | 1. Department of Medicine, The University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA;2. Department of Surgery, The University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA;3. Department of Biochemistry and Cancer Biology, The University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA;4. Center for Diabetes and Endocrine Research, The University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA |
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| Abstract: | The cyclic-AMP dependent protein kinase (PKA) signaling pathway regulates cell growth, development, metabolism, and gene expression. Peripheral blood of cancer patients but not normal individuals, shows increased catalytic subunit levels of PKA (PKAc). We showed here that this extracellular form of PKAc (ECPKA) from conditioned media of cultured cancer cells as well as purified PKAc inhibit angiogenesis, using the in utero chicken embryo chorioallantoic membrane assay. Inhibition of angiogenesis is partially reversed by PKI, a peptide inhibitor of PKA, thus suggesting an anti-angiogenic role for ECPKA. The significance of ECPKA in cancer is discussed. |
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| Keywords: | ECPKA Angiogenesis Extracellular PKA Chorioallantoic |
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