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Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma |
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| Authors: | Leopold Ludwig Franz Oswald Cuong Hoang-Vu Henning Dralle Eberhard Hildt Roland M. Schmid Wolfram Karges |
| Affiliation: | 1. Department of Internal Medicine II, Klinikum rechts der Isar, University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany;2. Zentrum für Innere Medizin, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany;3. Department of Surgery, University of Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany;4. Department of Internal Medicine, University of Freiburg, Hugstetter Strasse 49, 79106 Freiburg, Germany;5. Division of Endocrinology and Diabetes, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany |
| Abstract: | Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling. |
| Keywords: | Thyroid Cancer Tyrosine kinase Expression Oncogene |
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