鲨鱼软骨素对肿瘤患者T淋巴细胞亚群的影响

肿瘤的发生发展与机体免疫状态有密切关系 ,细胞免疫功能受抑制和手术创伤对机体免疫功能的影响 ,是肿瘤转移、复发和预后差的重要原因。近年来文献报道 :鲨鱼软骨含有强效的抑制肿瘤新生血管生长因子 ,不但可以防止癌细胞扩散和复发 ,还能激活T ,B细胞和巨噬细胞的功能 ,提高肿瘤患者机体免疫功能[1 ] 。我们通过检测中、晚期肿瘤患者手术后外周血T细胞亚群的变化 ,对鲨鱼软骨素的免疫调节作用进行初步探讨。材料与方法病例选择与分组经手术治疗的中、晚期肿瘤患者 16例 ,男性 14例 ,女性2例 ,年龄 48- 68岁。病理确诊胃癌 10例 ,直肠癌 …

Effect of Shark Chondroitin on T Lymphocyte Subsets of Cancer Patients

The objective of the study is to find out the effect of shark chondroitin on T lymphocyte subsets in cancer patients. Patients were divided into two groups. One group was treated with chemotherapy alone, and the other group was treated with chemotherapy plus shark chondroitin. Using immunofluorescence technique, T lymphocyte subsets in the peripheral blood were determined in two groups before and after chemotherapy. The results showed that CD4 /CD8 ratio increased in the patients received shark chondroitin. In the chemotherapy group, CD3 had no change, but CD4 decreased while CD8 increased significantly. The results suggest that shark chondroitin could enhance immune function in cancer patients, especially during chemotherapy.