THE ROLE OF RECOMBINANT HUMAN FUSION PROTEIN IL-6／IL-2 （CH925） IN HEPADNA VIRUS INFECTION TREATMENT

The affects of CH925,a novel immune modulator,on hepadns virus infection was evaluated.Day-old ducklings were inoculated intravenously with LJ-76 DHBV containing serum.Infected ducklings were then treated with the CH925 and the mixture of IL-2 and IL-6 intravenously and the control ducklings received equivalent normal saline (NS).Blood and liver samples were taken and assayed for DHBV DNV and/or DHBsAg.At the completion of the experiment there was a inhibition of viremia with the CH925 and IL-2 IL-6.Serum DHBV DNA was detected in 6 of 10 ducks in 100000unit/kg dossge group,7 of 10 ducks in 50000 unit/kg dosage group and 6 of 10 ducks in IL-2 IL-6 dosage group,compared with 9 of 10 NS control,and it showed a similar result in cireulating DHBsAg.When samples of liver DNA were processed for hybridization,a little difference in the DHBV DNA replication was noted between ducks receiving CH925,IL-2 IL-6 or NS placebo.It is suggested that CH925 might be a potential remedy in HBV infection treatment.