| 支架置入对颅内宽颈动脉瘤血流动力学的影响 |
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| 引用本文： | 杨新建.支架置入对颅内宽颈动脉瘤血流动力学的影响[J].中华医学杂志(英文版),2010,123(15):1999-2003. |
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| 作者姓名： | 杨新建 |
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| 作者单位： | ZHANG Yi-sen,YANG Xin-jian,ZHAO Yu-jing,ZHANG Ying,LUO Bin,LI Chuan-hui(Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China);WANG Sheng-zhang,CHEN Jia-liang(Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China);QIAO Ai-ke(College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100024, China);ZHANG Kun-ya,LIU Zhi-cheng(Department of Biomedical Engineering, Capital Medical University, Beijing 100050, China) |
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| 基金项目： | This study was supported by grants from the National Science Foundation of China，the Natural Science Foundation of Beijing，the Individual Item Assisted by Beijing Excellent Talents Program，High Level Health Technique Talent Training Plan of Beijing Health System |
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| 摘 要： | Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.Methods Three idealized plexiglass aneudsmal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics （CFD） simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.Results The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac.Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.Conclusions Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.
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| 关 键 词： | 血流动力学 动脉瘤 后支架 计算流体力学 CFD模拟 流场可视化 几何模型 几何形状 |
| 修稿时间： | 4/7/2010 12:00:00 AM |
Hemodynamic effects of stenting on wide-necked intracranial aneurysms |
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| ZHANG Yi-sen,YANG Xin-jian,WANG Sheng-zhang,QIAO Ai-ke,CHEN Jia-liang,ZHANG Kun-ya,LIU Zhi-cheng,ZHAO Yu-jing,ZHANG Ying,LUO Bin,LI Chuan-hui.Hemodynamic effects of stenting on wide-necked intracranial aneurysms[J].Chinese Medical Journal,2010,123(15):1999-2003. |
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| Authors: | ZHANG Yi-sen YANG Xin-jian WANG Sheng-zhang QIAO Ai-ke CHEN Jia-liang ZHANG Kun-ya LIU Zhi-cheng ZHAO Yu-jing ZHANG Ying LUO Bin LI Chuan-hui |
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| Institution: | [1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China [2]Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China [3]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100024, China [4]Department of Biomedical Engineering, Capital Medical University, Beijing 100050, China [5]Department of Biomedical Engineering, Capital Medical University, Beijing 100050, China |
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| Abstract: | Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.Methods Three idealized plexiglass aneudsmal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics (CFD) simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.Results The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac.Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.Conclusions Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization. |
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| Keywords: | intracranial aneurysm stents hemodynamics computational fluid dynamics |
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