| 成人朗格汉斯细胞组织细胞增生症5例临床病理分析 |
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| 引用本文： | 魏丽,杨冬梅,李雪. 成人朗格汉斯细胞组织细胞增生症5例临床病理分析[J]. 诊断病理学杂志, 2011, 18(6). DOI: 10.3969/j.issn.1007-8096.2011.06.007 |
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| 作者姓名： | 魏丽 杨冬梅 李雪 |
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| 作者单位： | 首都医科大学附属北京同仁医院病理科,北京,100730 |
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| 摘 要： | 目的 探讨成人朗格汉斯细胞组织细胞增生症(LCH)的临床病理学特征、免疫表型及预后.方法 分析5例成人LCH的临床病理学特点,同时用免疫组化染色观察LCH的免疫表型,采用原位分子杂交方法检测病变组织中EBV编码的小RNA(EBER).结果 5例成人LCH均为男性,发病年龄21～29岁.组织学改变为朗格汉斯细胞弥漫分布,细胞中等至偏大,胞质淡染至嗜酸,核呈圆形、卵圆形、咖啡豆样或不规则形,可见核沟和凹陷,间质富于小血管和纤维母细胞,并见不同程度的嗜酸性粒细胞、淋巴细胞及中性粒细胞浸润.免疫组化示朗格汉斯细胞S-100、CD68和CDla(+),p53不同程度(+),Ki-67增殖指数5％ ～ 15％.原位分子杂交示病变组织中EBER均(-).结论 成人LCH可以发生于颅眶、外耳道、肛周及背部皮肤,手术切除结合其他治疗,预后较好.
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| 关 键 词： | 成人 朗格汉斯细胞组织细胞增生症 临床病理 |
Langerhans cell histiocytosis in adults: a clinicopathologic analysis of 5 cases |
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| WEI Li,YANG Dong-mei,LI Xue. Langerhans cell histiocytosis in adults: a clinicopathologic analysis of 5 cases[J]. Chinese Journal of Diagnostic Pathology, 2011, 18(6). DOI: 10.3969/j.issn.1007-8096.2011.06.007 |
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| Authors: | WEI Li YANG Dong-mei LI Xue |
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| Affiliation: | WEI Li,YANG Dong-mei,LI Xue(Department of Pathology,Beijing Tong Ren Hospital,Capital Medical University,Beijing 100730,China) |
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| Abstract: | Objective To investigate the clinicopathologic features,immunophenotype and prognosis of Langerhans cell histiocytosis(LCH) in adults.Methods Analysis of 5 cases of clinical and pathological features of adult LCH,while the SP immunohistochemical staining were performed for LCH immune phenotype.The encoded small RNA was detected by in situ hybridization.Results The 5 adult patients with LCH were male,aged 21-29 years old.Histological changes included: diffused distribution of Langerhans cells,the cells mediu... |
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| Keywords: | Adult Langerhans cell histiocytosis Clinical pathology |
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