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| Galectin-3在甲状腺乳头状癌中的表达及意义 | |
| 引用本文： | 吴文君,许岚,刘晓,朱圣炜,刘国萍,孙荣超,杨树东. Galectin-3在甲状腺乳头状癌中的表达及意义[J]. 实用医学杂志, 2007, 23(3): 346-347 |
| 作者姓名： | 吴文君 许岚 刘晓 朱圣炜 刘国萍 孙荣超 杨树东 |
| 作者单位： | 1. 214002,江苏省无锡市第一人民医院内分泌科 2. 214002,江苏省无锡市第一人民医院普外科 3. 214002,江苏省无锡市第一人民医院病理科 |
| 基金项目： | 南京医科大学校科研和教改项目 |
| 摘 要： | 目的：比较galectin-3（Gal-3）在甲状腺乳头状癌和甲状腺良性病变中的表达差异，明确其临床意义。方法：采用免疫组化EnVision二步法检测214例甲状腺手术标本中Gal-3蛋白的表达情况。结果：甲状腺乳头状癌Gal-3蛋白表达阳性率为92．6％，显著高于结节性甲状腺肿（28．1％）、腺瘤（41．8％）及甲状腺炎（12．9％）。结论：Gal-3蛋白在甲状腺乳头状癌中的表达显著高于甲状腺良性病变，可作为甲状腺乳头状癌诊断的特异指标。 |
| 关 键 词： | 甲状腺肿瘤 癌,乳头状 |
| 修稿时间： | 2006-09-15 |
Expression of galectin-3 in papillary thyroid carcinoma |
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| WU Wen-jun,XU Lan,LIU Xiao,ZHU Shengwei,LIU Gao-ping,SUN Rong-chao,YANG Shu-dong. Expression of galectin-3 in papillary thyroid carcinoma[J]. The Journal of Practical Medicine, 2007, 23(3): 346-347 | |
| Authors: | WU Wen-jun XU Lan LIU Xiao ZHU Shengwei LIU Gao-ping SUN Rong-chao YANG Shu-dong |
| Affiliation: | Department of Endocrine, the Affiliated Wuxi First Hospital of Nanjing Medical University, Wuxi 214002, China |
| Abstract: | Objective To investigate the expression and its clinical significance of galectin-3 in papillary thyroid carcinoma and benign thyroid diseases. Methods Two hundred and fourteen samples of resected thyroid nodules were examined by En Vision immunohistochemical technique to detect the expression of galectin-3. Results The expression rate of galectin-3 was 92.6% in papillary thyroid carcinoma, 28.1% in nodular goiter, 41.8% in adenoma and 12.9% in thyroiditis. The positive expression rate of galectin-3 in papillary thyroid carcinoma was higher than that in benign thyroid diseases. Conclusion The expression of galectin-3 in papillary thyroid carcinoma is statistically higer than that in benison thyroid diseases, being acted as one of the diagnostic markers of papillary thyroid carcinoma. |
| Keywords: | Galectin-3 |
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