| 清开灵对东莨菪碱致小鼠学习记忆障碍的作用及脑内NO和NOS的影响 |
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| 引用本文： | 王永丽,问慧娟,李玉巧,韩璇,周雅静,魏芳.清开灵对东莨菪碱致小鼠学习记忆障碍的作用及脑内NO和NOS的影响[J].中药药理与临床,2011(2):107-109. |
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| 作者姓名： | 王永丽 问慧娟 李玉巧 韩璇 周雅静 魏芳 |
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| 作者单位： | 河北大学药学院河北省药物质量分析控制重点实验室;河北大学基础医学院;河北大学公共卫生学院; |
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| 基金项目： | 河北省科学技术研究与发展计划项目(10276105D-89) |
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| 摘 要： | 目的:研究清开灵对东莨菪碱致小鼠空间学习记忆障碍的作用及脑内一氧化氮(NO)和一氧化氮合酶(NOS)的影响。方法:东莨菪碱造模的雄性KM小鼠随机分为6组,正常对照组、模型对照组、清开灵20g/kg组、清开灵40g/kg、清开灵80 g/kg组和阳性对照药尼莫地平0.3g/kg组。给予等容积药物或蒸馏水,每日灌胃一次,连续30天。于末次给药后30min,除对照组腹腔注射生理盐水外,其它各组注射东莨菪碱2mg/kg,20min后进行Morris水迷宫测试,测试5天后处死,取其脑组织进行NO和NOS测定。结果:清开灵可明显改善东莨菪碱所致小鼠的空间学习记忆障碍,并可以降低小鼠脑内NO含量和NOS活性。结论:清开灵能明显改善东莨菪碱所致小鼠空间学习记忆障碍,并降低其脑内NO含量及NOS活性。
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| 关 键 词： | 清开灵 学习记忆 东莨菪碱 一氧化氮 一氧化氮合酶 |
Effects of Qingkailing on learning memory ability and cerebral nitric oxide and nitric oxide synthase in dementia model mice induced by scopolamine |
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| Wang Yongli,Wen Huijuan,Li Yuqiao,Han Xuan,Zhou Yajing,Wei Fang.Effects of Qingkailing on learning memory ability and cerebral nitric oxide and nitric oxide synthase in dementia model mice induced by scopolamine[J].Pharmacology and Clinics of Chinese Materia Medica,2011(2):107-109. |
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| Authors: | Wang Yongli Wen Huijuan Li Yuqiao Han Xuan Zhou Yajing Wei Fang |
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| Institution: | Wang Yongli1,Wen Huijuan2,Li Yuqiao2,Han Xuan2,Zhou Yajing2,Wei Fang3(1Pharmaceutical Sciences College,2 Basic Medicine College,3 Public Health College,Hebei University,Baoding 071000) |
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| Abstract: | Objective: To study the effect of Qingkailing in model mice by measuring learning and memory ability and some biochemical indexes in brain tissue.Methods: The Morris water maze was used to observe the learning and memory ability of model mice.Biochemical methods were used to determine the content of NO and the activity of NOS in brain tissue.Results:(1) Qingkailing could significantly improve the memory of model mice(2) Compared with the control group,Qingkailing could decrease the activities of NOS and the... |
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| Keywords: | Qingkailing learning and memory NO NOS |
| 本文献已被 CNKI 等数据库收录！ |
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