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| 云木香对豚鼠离体肠平滑肌的影响 | |
| 引用本文： | 张猛,郭建生,聂子文,刘红艳,陈君. 云木香对豚鼠离体肠平滑肌的影响[J]. 中药药理与临床, 2011, 0(6): 73-76 |
| 作者姓名： | 张猛 郭建生 聂子文 刘红艳 陈君 |
| 作者单位： | 湖南中医药大学;湖南省教育厅中药学现代化研究重点实验室;国家中药管理局药性与药效研究三级实验室; |
| 基金项目： | 国家科技部973资助项目:中药药性理论相关基础问题研究(2007CB512603); 湖南省科技计划项目; 湖南省中药重点学科 |
| 摘 要： | 目的:观察云木香水煎液、水提液、醇提液、挥发油对豚鼠离体肠平滑肌的作用,并探讨云木香对豚鼠离体肠平滑肌作用的物质基础。方法:以给药前后3分钟豚鼠离体肠平滑肌平均振幅为观测指标,采用BL-420F生物机能实验系统,观察并比较云木香四种提取液对豚鼠离体肠平滑肌的作用情况。结果:云木香水煎液、醇提液、挥发油能显著降低豚鼠正常离体肠平滑肌的平均振幅(P<0.01),小剂量水提液能升高豚鼠正常离体肠平滑肌的平均振幅(P<0.05);四种提取液均能降低乙酰胆碱所致痉挛状态下的豚鼠离体肠平滑肌的平均振幅。结论:小剂量云木香水提液能兴奋豚鼠正常离体肠平滑肌,水煎液、醇提液、挥发油能够抑制豚鼠离体肠平滑肌的自主活动;四种云木香提取液均能拮抗乙酰胆碱所致痉挛状态下的豚鼠离体肠平滑肌。 |
| 关 键 词： | 云木香 水煎液 水提液 醇提液 挥发油 豚鼠 离体肠 |
Effect of Yunmuxiang extract on isolated intestinal smooth muscle of guinea pig |
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| Zhang Meng,,Guo Jiansheng,,Nie Ziwen,Liu Hongyan,Chen Jun. Effect of Yunmuxiang extract on isolated intestinal smooth muscle of guinea pig[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(6): 73-76 | |
| Authors: | Zhang Meng Guo Jiansheng Nie Ziwen Liu Hongyan Chen Jun |
| Affiliation: | Zhang Meng1,2,Guo Jiansheng1,3,Nie Ziwen1,Liu Hongyan1,Chen Jun1,2(1 Hunan University of Chinese Medicine,2 Hunan Province Education Department,Key Lab of Modernization of Chinese Medicine,3 Tertiary Laboratory of Property and Efficacy Research of Chinese Medicine of State Administration of Chinese Medicine,Changsha 410208) |
| Abstract: | Objective:To study the effect of decoction,aqueous extract,ethanol extract,essential oil of Yunmuxiang on isolated intestinal smooth muscle of guinea pig and to find the material basis of Yunmuxiang which affact isolated intestinal smooth muscle of guinea pig.Methods:seeing the average amplitude of isolated intestinal smooth muscle of guinea pig of 3 minutes before and after the administration as an Indicator,using experimental system of BL-420F biological function,to observe and compare the effect of four ... |
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