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| 牛膝饮片及牛膝多糖对小鼠免疫抑制调节作用的研究 | |
| 引用本文： | 崔维,吴国学,张振凌.牛膝饮片及牛膝多糖对小鼠免疫抑制调节作用的研究[J].中国实验方剂学杂志,2011,17(16):141-143. |
| 作者姓名： | 崔维 吴国学 张振凌 |
| 作者单位： | 1. 河南中医学院,郑州,450008;河南中医学院第三附属医院,郑州,450008 2. 河南中医学院,郑州,450008;郑州人民医院,郑州,450003 3. 河南中医学院,郑州,450008 |
| 基金项目： | 国家十一五科技支撑计划项目 |
| 摘 要： | 目的:研究牛膝饮片及其有效成分牛膝多糖对免疫功能的影响,探讨二者作用的一致性。方法:将昆明种小鼠分为空白对照组、模型组、牛膝饮片组、牛膝多糖组及香菇菌多糖阳性对照组,ip环磷酰胺3 d造成小鼠免疫抑制模型,同时分别ig生理盐水及相应药物7 d后测定牛膝饮片、牛膝多糖对小鼠胸腺、脾脏质量、吞噬百分率、吞噬指数、溶血素、溶血斑以及淋巴细胞转化率的影响。结果:牛膝饮片、牛膝多糖均能提高环磷酰胺造成免疫抑制模型小鼠胸腺、脾脏质量、吞噬百分率、吞噬指数,促进溶血素、溶血斑形成,提高淋巴细胞转化率;与模型组相比,两者均能提高免疫抑制小鼠各免疫指数,且差异显著(P<0.01或P<0.05);在本实验用药剂量下(牛膝饮片20 g.kg-1,牛膝多糖0.5 g.kg-1)2者作用强度相当。结论:牛膝多糖是牛膝中增强免疫的主要有效成分。 |
| 关 键 词： | 牛膝 牛膝多糖 免疫 |
| 收稿时间： | 2011/1/22 0:00:00 |
Effects of Achyranthis Bidentatae Radix and Achyranthes Bidentata Polysaccharides on Enhancing Immune Function |
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| CUI Wei,WU Guo-xue and ZHANG Zhen-ling.Effects of Achyranthis Bidentatae Radix and Achyranthes Bidentata Polysaccharides on Enhancing Immune Function[J].China Journal of Experimental Traditional Medical Formulae,2011,17(16):141-143. | |
| Authors: | CUI Wei WU Guo-xue and ZHANG Zhen-ling |
| Institution: | CUI Wei1,2,WU Guo-xue1,3,ZHANG Zhen-ling1(1.Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China,2.The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,3.People's Hospital of Zhengzhou,Zhengzhou 450003,China) |
| Abstract: | Objective: To study the effect of Achyranthis Bidentatae Radix and achyranthis bidentatae polysaccharides(ABPS) on the mice's immune function,and investigate the consistency of both effects.Method: Kunming mice were divided into 5 groups: blank control group,immunosuppression model group,decoction group of Achyranthis Bidentatae Radix,ABPS group and mushroom polysaccharides group.The immunosuppression model of mouse was established with injecting cyclophosphamide abdominally.The effects of the decoction of ... |
| Keywords: | Achyranthis Bidentatae Radix achyranthis bidentatae polysaccharides immunity |
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