长期应用小剂量氨茶碱对稳定期慢性阻塞性肺疾病患者、动物外周血、骨髓粒细胞增殖的影响

目的探讨长期应用小剂量氨茶碱（Aminophyllin,AP）对稳定期慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease,COPD）患者、动物骨髓、外周血粒细胞增殖的影响。方法 （1）应用前瞻、随机分组、对照及自身对照的方法,将1252例稳定期COPD患者（Ⅱ～Ⅲ级）分为治疗组（常规治疗＋茶碱缓释片0.4g/d）和对照组（常规治疗）。治疗开始后每间隔15d复查1次血常规,对治疗前后的指标进行自身前后比较。（2）25只实验用羊采用自身对照法,在应用AP 3mg/（kg.d）后,对治疗前后的各项指标进行自身前后比较。结果 （1）长期应用小剂量AP,对稳定期COPD患者的外周血粒细胞增殖无影响（P〉0.05）;（2）长期应用小剂量AP可使动物的骨髓嗜酸性粒细胞增生活跃（P〈0.05）;（3）长期应用小剂量AP对动物的骨髓、外周血粒细胞增生无影响（P〈0.05）。结论长期应用小剂量AP可使骨髓嗜酸性粒细胞增生活跃以提高机体抗炎及调节免疫能力,而对骨髓血红系统及外周血粒细胞增殖无影响。

The effect of long-term use of low-dose aminophylline on stable chronic obstructive pulmonary disease,animal blood,bone marrow granulocyte proliferation

【Objective】 To explore the effect of long-term use of low-dose aminophylline on stable patients with chronic obstructive pulmonary disease、animal bone marrow、peripheral blood granulocyte proliferation.【Methods】（1）Using prospective studies、random allocation、controlled and self-control methods,we divided 1500 stable COPD patients（GradeⅡ-Ⅲ） into treatment group（Conventional therapy＋Oral theophylline0.4g/day） and control group（Conventional therapy）.Group and self comparisons were made for indications before and after treatment.（2）Using self-control method,indications of 25 experimental sheep with AP3mg mg/（kg·d）]in treatment were compared before and after.【Results】（1）There was no effect of long-term use of low-dose AP on granulocytes proliferation in peripheral blood of patients with stable COPD（P 0.05）.（2）The long-term use of low-dose AP could stimulate the eosinophils proliferation in bone marrow of animals（P 0.05）.（3） There was no influnce on granulocytes proliferation in peripheral blood and bone marrow of animals after long-term application of low-dose AP（P 0.05）.【Conclusion】 The long-term use of low dose AP causes active eosinophilic granulocyte proliferation in bone marrow so as to promote the ability of anti-inflammatory and immunoregulation,but there is no effect on the proliferation of granulocytes in peripheral blood.