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| 金雀异黄素壳聚糖微球胶囊的体内药动学研究 | |
| 引用本文： | 吴婉莹,李云谷. 金雀异黄素壳聚糖微球胶囊的体内药动学研究[J]. 中药材, 2002, 25(4): 282-284 |
| 作者姓名： | 吴婉莹 李云谷 |
| 作者单位： | 北京中医药大学药学院,北京,100102 |
| 摘 要： | 目的:比较金雀异黄素壳聚糖微球胶囊(M.C)与普通胶囊(C.C)的动物体内分布情况,探讨新制剂微球胶囊是否具有缓释靶向性。方法:采用高效液相色谱法分析,3P97软件拟合,进行微球胶囊与普通胶囊的体内药动学研究。结果:微球胶囊在体内各脏器的浓度与普通胶囊相比降低较缓慢,可以在较长时间维持一定的药物浓度;金雀异黄素普通胶囊在小鼠体内分布以肝脏为主,微球胶囊在体内分布与之相比有明显改变,以肺与脾脏为主。结论:金雀异黄素聚糖微球胶囊具有较好的缓释性,并在分布上对肺脾具有较高的选择性。 |
| 关 键 词： | 金雀异黄素 壳聚糖 微球 体内药动学 |
| 修稿时间： | 2002-02-04 |
Internal Pharmacokinetical Study on Genistein Chitosan Microsphere Capsule |
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| Wu Wanying,Li Yungu. Internal Pharmacokinetical Study on Genistein Chitosan Microsphere Capsule[J]. Journal of Chinese medicinal materials, 2002, 25(4): 282-284 | |
| Authors: | Wu Wanying Li Yungu |
| Affiliation: | College of Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102. |
| Abstract: | Objectivre:To compare the distribution of genistein chitosan microsphere capsule (M.C) in vivo in rats with that of genistein common capsule (C.C).To research slow-released target microsphere capsule. Method: The study on pharmacokinetics of M.C and C.C were analyzed by HPLC and 3P97 software. Results : The concentrations of M. C distributed among various organs decreased slower than those of C. C and were able to keep a certain concentration for a long time.Genistein common capsule mainly distributed in livers of rats, while genistein chitosan microsphere capsule distributed mainly in lungs and spleens of rats. Conclusion: The chitosan microsphere capsule of genistein has better slow-release and has tendency to distribute in lungs and spleens. |
| Keywords: | Genistein Chitosan Microsphere Internal pharmacokinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |