家中应用芬太尼透皮贴剂治疗中重度癌症痛疗效观察

目的探讨应用芬太尼透皮贴剂(多瑞吉)在家中治疗中、重度癌症痛患者的可行性和治疗效果。方法由专业医师组成治疗小组,对116例中、重度癌症痛患者应用芬太尼透皮贴剂,在家中实施镇痛治疗,初始剂量为25μg/h或参照吗啡与芬太尼剂量转换公式计算。贴剂每72 h更换1次,其间根据患者的疼痛程度进行剂量调整,并进行疼痛缓解度和生活质量评分与观察随访。结果116例中、重度癌症痛患者的疼痛缓解率为98.27%,患者治疗的依从性好,生活质量明显提高。治疗剂量最小为25μg/h,最大为375μg/h,平均治疗时间为90.5 d。主要的不良反应有头晕、恶心、便秘和皮肤过敏。结论芬太尼透皮贴剂是一种使用方便、不良反应较轻、疗效确定的镇痛药,适宜中、重度癌症痛患者在家中使用。

Analgesic Effect of Transdermal Fentanyl to Moderate or Severe Cancer Patients Treated at Home

Objective To assess the analgesic effects of Transdermal Fentanyl(Durogesic) to moderate or severe cancer patients treated at home.Methods 116 moderate or severe cancer patients with pain received a pain relieving treatment offered by a group of qualified doctors.The trial dosage of Transdermal Fentanyl is 25 μg/h or dosages referred to a conversion formula from morphine to Transdermal Fentanyl.The plaster will be changed with a new one after every 72 h.Dosage could be adjusted according to patients'reaction.Results After follow-up interviews, the effects and adverse reactions of Durogesic were observed.98.27% of patients were observed to relieve pain and the quality of life was significantly improved after use of Transdermal Fentanyl.The minimum dosage of Transdermal Fentanyl was 25 μg/h and the maximum 375 μg/h, average time of treatment was(90.5) d.The main adverse reactions were dizziness, nausea, constipation and skin allergy.Conclusion In summary, Transdermal Fentanyl is a kind of ideal analgesic which has the advantage of convenience and low rate of adverse reactions.It suits moderate or severe cancer patients who treated at home.