| 人类男性Y染色体变异对男性生育力影响的临床分析 |
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| 引用本文： | 张清健,郑立新,田佩玲,叶嘉玲,杨卫,王柏贤,李铭臻,冯苗.人类男性Y染色体变异对男性生育力影响的临床分析[J].中国计划生育学杂志,2006,14(5):289-292. |
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| 作者姓名： | 张清健 郑立新 田佩玲 叶嘉玲 杨卫 王柏贤 李铭臻 冯苗 |
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| 作者单位： | 广东省计划生育科研所,广州,510600 |
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| 摘 要： | 目的:探讨Y染色体异常对男性生育能力的影响。方法:对因不育而就诊的4 238例男性患者进行G显带核型分析。结果:共检出Y染色体异常核型550例,占全部被检者12．98％,其中大Y 染色体异常497例;小Y染色体21例;倒位染色体13例;缺失Y染色体12例;47,XYY 4例;45,XO／ 46,XY嵌合体3例;48,XXYY 1例;环状Y染色体1例;Y染色体的平衡易位46,X,t(Y;17)(q12; q25)1例、46,X,t(Y;3)(q11;p11)1例、46,X,t(Y;14)(q12;q22)1例和1例46,X,t(Y;15) (p11;q13)。结论:Y染色体数目与形态结构的异常对男性生育能力有重要影响。
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| 关 键 词： | Y染色体变异 男性不育 核型分析 |
| 收稿时间： | 2005-12-09 |
| 修稿时间： | 2006-02-13 |
Influence of Y Chromosome Abnormality on Male Reproductive Ability |
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| Zhang Qingjian, Zheng lix- ing, Tian Peiling,et al..Influence of Y Chromosome Abnormality on Male Reproductive Ability[J].Chinese Journal of Family Planning,2006,14(5):289-292. |
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| Authors: | Zhang Qingjian Zheng lix- ing Tian Peiling |
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| Institution: | Provincial Research Institute for Family Planning, Guangdong 510600 |
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| Abstract: | Objective: To investigate the influence of Y chromosome abnormality on male reproductive ability. Methods: Karyotyping analysis by G-banding was carried out in 4,238 infertile men. Results: 550 cases of Y chromosome abnormality were observed in 4,238 patients , accounting for 12.98% , including 497 cases of big Y chromosome abnormality; 21 cases of bit Y chromosome abnormalities; 13 cases of inversion of Y chromosome; 12 cases of Y chromosome deletion; 4 cases of 47, XYY; 3 cases of 45, X0/ mosaic 46, XY; 1 case of 48, XXYY; 1 case of circular Y chromosome. Among the patients with Y chromosome balanced translocation, 1 case was 46, X, t (Y; 17)(q12; q25) , 1 case was 46, X, t (Y; 3) (q11; p11) , 1 case was 46,X, t (Y; 14)(q12; q22) , and 1 case was 46,X, t( Y; 15) ( p11;q13). Conclusion: It shows an important impact of Y chromosome abnormality on male reproductive ability. |
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| Keywords: | Y chromosome abnormality Male infertility Karyotype analysis |
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