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| N-(1-乙氧羰基-3-苯氨甲酰基丙基)甘氨酰甘氨酸衍生物的合成 | |
| 引用本文： | 李彩萍,龚康孙,蔡纯一,赵满琼. N-(1-乙氧羰基-3-苯氨甲酰基丙基)甘氨酰甘氨酸衍生物的合成[J]. 药学学报, 1994, 29(10): 730-738 |
| 作者姓名： | 李彩萍 龚康孙 蔡纯一 赵满琼 |
| 作者单位： | 成都华西医科大学药学院,成都610041;*本校1989届硕士研究生;***本校1990届本科生 |
| 摘 要： | 报道4个N-(1-[1-乙氧羰基-3-(对甲)苯氨甲酰基]丙基甘氨酰｝-N-取代甘氨酸(XI1～4)和5个1-[1-乙(或甲)氧羰基-3-(对甲)苯氨甲酰基]丙基-4-取代-1,4-哌嗪-2,5-二酮(XII1～5)共9个估计有血管紧张素转化酶抑制活性化合物的合成和鉴定。所有这些化合物及9个相应的酯(X1～9)均未见文献报道。药理初试结果,化合物XII2,XII5,XI4和XII1均有较强降压活性。 |
| 关 键 词： | 取代甘氨酰甘氨酸 取代1 4-哌嗪-2 5-二酮 N-取代甘氨酸酯 N-邻苯二甲酰-γ-谷氨酰苯胺 |
| 收稿时间： | 1993-11-22 |
SYNTHESIS OF N-(1-CARBETHOXY-3-PHENYLCARBAMOYLPROPYL) GLYCYL GLYCINE DERIV ATIVES |
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| CP Li,KS Gong,CY Cai and MQ Zhao. SYNTHESIS OF N-(1-CARBETHOXY-3-PHENYLCARBAMOYLPROPYL) GLYCYL GLYCINE DERIV ATIVES[J]. Acta pharmaceutica Sinica, 1994, 29(10): 730-738 | |
| Authors: | CP Li KS Gong CY Cai MQ Zhao |
| Abstract: | Four N-(1-carbethoxy-3-phenylcarbamoylpropyl)glycyl glycine derivatives(XI1～4)and five 1-(1-carbethoxy-3-phenylcarbamoyl)propyl-1,4-piperazine-2,5-dione derivatives(XII1～5)expected to have inhibitory activity on angiotensin-converting enzyme were synthesized.All of the compounds mentioned above and nine corresponding esters(X1～9)were not reported in literature.In preliminary test in rats,compounds XII2 and XII5 showed marked hypotensive activity. |
| Keywords: | 1,4-Piperazine-2,5-dione substituted N-Substituted glycine ester N-Phthalyl-γ-glutamylaniline N-γ-Glutamylaniline Angiotensin-converting enzyme inhibitor(ACEI) Glycylglycine substituted |
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