| 雷公藤单─有效成分T4对类风湿关节炎患者滑膜细胞产生前列腺素E2的影响 |
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| 引用本文： | 要庆平,张乃峥. 雷公藤单─有效成分T4对类风湿关节炎患者滑膜细胞产生前列腺素E2的影响[J]. 药学学报, 1994, 29(10): 790-792 |
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| 作者姓名： | 要庆平 张乃峥 |
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| 作者单位： | 北京协和医院,北京 100730 |
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| 摘 要： |
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| 关 键 词： | 雷公藤T4 类风湿关节炎 滑膜细胞 前列腺素E2 |
| 收稿时间： | 1994-04-25 |
EFFECTS OF TRIPCHLOROLIDE (T4) OF TRIPTERYGIUM WILFORDII HOOK ON THE PRODUCTION OF PROSTAGLANDIN E2 BY SYNOVIAL CELLS OF RHEUMATOID ARTHRITIS PATIENTS |
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| QP Yao and NZ Zhang. EFFECTS OF TRIPCHLOROLIDE (T4) OF TRIPTERYGIUM WILFORDII HOOK ON THE PRODUCTION OF PROSTAGLANDIN E2 BY SYNOVIAL CELLS OF RHEUMATOID ARTHRITIS PATIENTS[J]. Acta pharmaceutica Sinica, 1994, 29(10): 790-792 |
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| Authors: | QP Yao and NZ Zhang |
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| Abstract: | The effects of tripchlorolide ,an active ingredient(T4)of Tripterygium uilfordii Hook on the production of prostaglandin E2(PGE2)by synovial cells of rheumatoid arthritis(RA)patients were investigated.Six cases of definite RA(female 5,male 1,mean age 45 with an average course of disease of 9 years )were selected.Surgically obtained synovium specimen were dissociated into digested synovial single cells(DSSC). The cells were incubated with various concentrations of T4 for 48 hours.Using radioimmunoassay T4 was found to significantly inhibit the production of PGE2(control 6.10±2.30vs T4 treated 0.58±0.17×10-5 mol·L-1) by short-term cultured DSSC of RA patients. The result of this study suggests that T4 may be useful in the forthcoming treatment of RA due to its inhibition of production of PGE2 by synovial cells. |
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| Keywords: | Rhcumatoid arthritis Synovial cells Prostaglandin E2 Tripchlorolide(T4) |
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