动脉瘤性蛛网膜下腔出血患者的认知功能损害

目的蛛网膜下腔出血的原因主要是颅内动脉瘤破裂.目前对颅内动脉瘤的治疗效果有了很大提高,很多患者在神经功能方面能得到基本恢复.但其中有部分患者仍存在认知功能损害,影响患者生活质量.蛛网膜下腔出血后认知功能检查成为近年来逐渐引起重视的问题.资料来源应用计算机检索PUBMED中相关文章,检索词"aneurysmalsubarachnoid hemorrhage;cognitive deficit",并限定文章语言为英文.并用计算机检索2001/2004期间相关文章.文章语言为中文或英文,检索词"蛛网膜下腔出血;认知功能;动脉瘤"和"subarachnoidhemorrhage;cognitive deficit".资料选择选择采用标准化测量方法并以认知功能测定为主要内容的文章.资料提炼共收集到101篇相关论文,其中15篇与本文内容高度相关,排除的其他论文中有部分内容为认知测量,排除新的认知功能测量方法介绍的论文.资料综合对所选论文的认知功能测量内容、方法、结果及影响因素进行分析.蛛网膜下腔出血本身及其并发症和治疗措施均可对认知功能的发生和程度产生影响.结论动脉瘤性蛛网膜下腔出血患者存在认知功能损害,造成认知损害的因素除蛛网膜下腔出血本身外,还有手术、麻醉、药物等因素.

Cognitive impairment in patients with aneurysmal subarachnoid hemorrhage

OBJECTIVE: Aneurysmal subarachnoid hemorrhage is mainly due to intracranial aneurysm rupture. Modern techniques enable most survivors to make a good functional recovery Nevertheless,it has been suggested that such patients suffer from a persistent disturbance of cognitive function,which affects their life quality. Therefore,cognitive assessment following aneurysmal subarachnoid hemorrhage has been gradually drawing increasing attention in recent years.DATA SOURCES: Related literature was searched through the computer in PUBMED with key terms of "aneurysmal subarachnoid hemorrhage" and"cognitive deficit" and the language was limited to English. Meanwhile literature between 2001 an.d 2004 was also searched with key terms of"subarachnoid hemorrhage" and "cognitive function" in the Chinese or English language,respectively.STUDY SELECTION: Literature with cognitive assessment as its main index determined by standardized measurement was enrolled in this study.DATA EXTRACTION: A total of 101 related articles were collected,including 15 ones closely related to the present study,while those with cognitive assessment as part of their content and cognitive function determined with new methods were excluded.DATA SYNTHESIS: Cognitive assessment was analyzed in respect of its content,measurement,results and risk factors. Effect of aneurysmal subarachnoid hemorrhage itself and its complications,as well as therapeutic methods on the onset and development of cognitive disturbance were also explored.CONCLUSION: Patients with aneurysmal subarachnoid hemorrhage suffer from cognitive impairment,which also results from operation,anesthesia and drugs.