食管癌患者放疗期间体质量下降的影响因素分析

目的 探讨食管癌患者放疗期间体质量下降的影响因素.方法 选取102例接受放疗的食管癌患者为研究对象,收集患者放疗期间的体质量、人口学资料、饮食摄入量、疾病治疗资料、放疗副反应和安德森症状评估量表评分情况,采用多元逐步回归方法分析放疗期间患者体质量下降的影响因素.结果 102例患者放疗前后体质量下降0～5.00 kg,平均（1.64±0.69） kg.多元回归分析显示,体质量下降与能量摄入低（x1）、消化道反应（x2）、肿瘤分期（x3）和放疗剂量（x4）有关,回归方程为y=-0.182＋0.142x1＋0.245x2 ＋0.210x3 ＋0.605x4.结论 维持能量摄入和预防消化道副反应对控制食管癌患者体质量的下降趋势至关重要.

Factors analysis of weight loss during radiotherapy in patients with esophageal cancer

Objective To identify factors associated with weight loss during radiotherapy （RT） in patients with esophageal cancer.Methods One hundred and two esophageal cancer patients who received radiotherapy were enrolled as our subjects.Patients＇ weight,characteristics,dietary intake,tumor and treatment data,acute adverse effects were collected.Anderson Symptom Inventory was performed.Multiple linear regression analysis was applied to identify independent factors with weight loss during RT.Results The average weight loss during RT was （1.64 ± 0.69） kg,ranged from 0 to 5.00 kg.Multiple regression analysis showed that the weight loss was associated with lower dietary energy intake （x1）,digestive adverse effect （x2）,TNM stage （x3） and radiation dose（x4）.The regression equitation was y =-0.182 ＋ 0.142x1 ＋ 0.245x2 ＋ 0.210x3 ＋0.605x4.Conclusion Maintaining energy intake and preventing and treating digestive adverse effects are two important measurement in esophageal cancer patients during RT.