肺结核化疗期类赫氏反应42例临床分析

目的 探讨类赫氏反应的临床特点、治疗及预后.方法 分析我院2008~2012年收治的42例类赫氏反应病例的临床特点、诊断、治疗及预后.结果 类赫氏反应发生率为0.93%,平均年龄（28.0±0.9）岁,多发生于肺结核初治病例抗结核治疗1~2个月间,病灶呈暂时性恶化表现.结论 类赫氏反应多发生于肺结核初治年轻病例,病情恶化呈暂时性及一过性表现,临床经对症处理后常很快缓解,预后良好,无须调整抗结核治疗方案.

Clinical analysis of 42 tuberculosis patients with Herxheimer reaction during chemotherapy

Objective To explore the clinical characteristics, treatment and prognosis of tterx- heimer reaction. Methods To analyze the clinical features,diagnosis,treatment and prognosis in 42 cases with Herxheimer reatoin recruited from 2008 to 2012 in our hospital. Results The incidence rate of Herx- heimer reatoin was 0.93% , mean age of the patients were（28.0 ±0.9 ） years. Herxheimer reatoin usually occurred in the initial 1 to 2 month of the treatment with anti-tuberculosis medicine ,the lesions manifested temporary deterioration. Conclusion Herxheimer reaction occurs in younger patients with untreated tuberculosis ,disease progression was temporary and transient. It can be relieved soon after symptomatic treatment. The prognosis is good, and there is no need to adjust the anti-tuberculosis treatment.