| 丹参多酚酸提取物中异紫草酸的结构确定 |
| |
| 引用本文： | 田介峰,李淑明,罗学军,李瑞明,霍志鹏,张双,旷文静,何毅.丹参多酚酸提取物中异紫草酸的结构确定[J].中草药,2023,54(9):2710-2715. |
| |
| 作者姓名： | 田介峰 李淑明 罗学军 李瑞明 霍志鹏 张双 旷文静 何毅 |
| |
| 作者单位： | 天士力医药集团股份有限公司研究院现代中药开发中心, 天津 300410;天士力医药集团股份有限公司创新中药关键技术国家重点实验室, 天津 300410;天士力医药集团股份有限公司创新中药关键技术国家重点实验室, 天津 300410;天士力医药集团股份有限公司研究院临床医学中心, 天津 300410;沈阳药科大学药学院, 辽宁 沈阳 110016;中国药科大学中药学院, 江苏 南京 211198 |
| |
| 基金项目： | 国家科技重大专项重大新药创制项目“中医药优势领域的创新中药关键技术开发研究”（2017ZX09301005） |
| |
| 摘 要： | 目的 确定从丹参多酚酸提取物中分离得到的1个紫草酸同分异构体(异紫草酸)的结构。方法 利用质谱、核磁共振、化学转化以及ECD等方法确定其化学结构。结果 该化合物鉴定为(2S,3S)-4-(2-羧基乙烯基)-2-(3,4-二羟基苯基)-2,3-2H-7-羟基-3-苯骈呋喃羧酸-3-(1R)-1-羧基-2-(3,4-二羟基)乙基]酯](异紫草酸)。结论 总结了紫草酸同分异构体核磁数据的规律，进一步明确了异紫草酸的平面结构并首次确定了异紫草酸的立体结构。
|
| 关 键 词： | 丹参多酚酸 异紫草酸 紫草酸 化学结构 立体结构 |
| 收稿时间： | 2022/11/27 0:00:00 |
Structure elucidation of a lithospermic acid isomer from extract of salvia polyphenolic acids |
| |
| TIAN Jie-feng,LI Shu-ming,LUO Xue-jun,LI Rui-ming,HUO Zhi-peng,ZHANG Shuang,KUANG Wen-jing,HE Yi.Structure elucidation of a lithospermic acid isomer from extract of salvia polyphenolic acids[J].Chinese Traditional and Herbal Drugs,2023,54(9):2710-2715. |
| |
| Authors: | TIAN Jie-feng LI Shu-ming LUO Xue-jun LI Rui-ming HUO Zhi-peng ZHANG Shuang KUANG Wen-jing HE Yi |
| |
| Institution: | Development Center of Modern Chinese Medicine, Research Institute of Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China;State Key Laboratory of Critical Technology in Innovative Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China;State Key Laboratory of Critical Technology in Innovative Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China;Clinical Medical Center, Research Institute of Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China |
| |
| Abstract: | Objective To determine the chemical structure of an isomer of lithospermic acid isolated from extract of salvia polyphenolic acids. Methods MS, NMR, Chemical conversion, and ECD were used to determine the chemical structure of the isolated lithospermic acid isomer. ResultsThe isomer of lithospermic acid was elucidated to be (2S,3S)-4-(1E)-2-carboxyethenyl)]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid 3-(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl]ester (isolithospermic acid). Conclusion The planer structure of isolithospermic acid is confirmed by the empirical rule summarized through the analysis of the lithospermic acid isomers'' NMR data, and its stereochemical structure is determined for the first time. |
| |
| Keywords: | salvia polyphenolic acid isolithospermic acid lithospermic acid chemical structure stereochemical structure |
|
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
