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A Novel Etiology of Hypophysitis: Immune Checkpoint Inhibitors
Affiliation:1. Department of Medicine (Endocrinology, Diabetes and Metabolism), Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Mail Code L607, Portland, OR 97239, USA;2. Department of Neurological Surgery, Oregon Health & Science University, 3303 South Bond Avenue, Mail Code CH8N, Portland, OR 97239, USA;3. Pituitary Center, Oregon Health & Science University, 3303 South Bond Avenue, Mail Code CH8N, Portland, OR 97239, USA;1. Department of Medicine: Endocrinology and Metabolism, Emory University, Atlanta, GA 30322, USA;2. Department of Neurosurgery, Emory University, Atlanta, GA, USA;1. Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, National Institute for Health Research, Cambridge Biomedical Research Centre, Addenbrooke''s Hospital, Hills Road, Cambridge CB2 0QQ, UK;2. Department of Nuclear Medicine, Addenbrooke''s Hospital, Hills Road, Cambridge CB2 0QQ, UK;3. Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge & Addenbrooke''s Hospital, Cambridge CB2 0QQ, UK;1. Endocrinology Division, Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho – Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255, 9° andar – Setor 9, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil;2. Neuroendocrinology Division, Instituto Estadual do Cérebro Paulo Niemeyer, 156th Resende Street, Rio de Janeiro, RJ, Brazil;3. Endocrinology Division, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil;4. Neuropatology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
Abstract:
Keywords:Hypophysitis  Adrenal insufficiency  Endocrine dysfunction  Immune checkpoint inhibitors  Immunotherapy  T lymphocytes  Cytotoxic T-lymphocyte-associated protein 4  Programmed cell death
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