MUC1联合MUC2在结直肠腺瘤及结直肠癌中联合表达与临床病理的相关性研究

目的探讨黏蛋白MUC1、MUC2在结直肠腺瘤及结直肠癌中联合表达与临床病理参数间相关性。方法应用免疫组织化学方法检测MUC1、MUC2在20例结直肠腺瘤和60例结直肠癌中的表达。结果 1MUC1、MUC2在20例结直肠腺瘤及60例结直肠癌中,阳性表达率分别为10%、46.7%(P=0.013);100%、58.3%(P=0.000)。2MUC1黏蛋白在结直肠癌中的表达与肿瘤的分化程度呈负相关(P=0.006),在低分化结直肠癌中表达强,并与浸润深度(P=0.004)、淋巴结转移(P=0.01)、Dukes分期(P=0.033)呈正相关,与预后呈负相关。3MUC2的表达与分化程度无关(P=0.143),而与浸润深度(P=0.016)、淋巴结转移(P=0.002)、Dukes分期(P=0.005)呈负相关,与生存期呈正相关。4MUC1、MUC2联合检测表明:MUC1与MUC2呈负相关,MUC2+MUC1-预后最好、MUC1+MUC2-预后最差。结论 MUC1的上调表达或MUC2的下调表达可能参与了结直肠癌的发生、发展、浸润及转移,对临床上判断预后具有较大意义。

Combined expression and clinicopathological correlation study of MUC1 and MUC2 in colorectal adenomas and colorectal carcinoma

Objective To explore the relationship between the combined expression of mucin MUC1 and MUC2,and the clinicopathological parameters in colorectal adenoma and colorectal carcinoma.Methods The expression of MUC1 and MUC2 were detected in 20 colorectal adenomas and 60 colorectal carcinomas by immunohistochemical method.Results The positive expression rates of MUC1 and MUC2 in 20 colorectal adenoma and 60 colorectal carcinomas were 10％ and 46.7％（P ＜0.05）;100％ and 58.3％（P ＜ 0.05）,respectively.The expression of mucin MUC1 was negatively correlated with the degree of differentiation（P ＜0.05）,but positively correlated with the depth of invasion（P ＜0.05）,lymph node metastasis（P ＜0.05）,Dukes＇ staging（P ＜0.05）.Mucin MUC2 expression was unrelated to differentiation （P ＞0.05）,but negatively correlated with the depth of invasion（P ＜0.05）,lymph node metastasis（P＜ 0.05） and Dukes＇ staging（P ＜0.05）.The combined detection of MUC1 and MUC2 showed that MUC1 was negatively correlated with MUC2.The expression of MUC2＋MUC1-gave the best prognosis,while MUC1＋MUC2 gave the worst prognosis.Conclusion The up regulation of MUC1 expression or downregulation of MUC2 expression might be involved in the carcinogenesis,progression,invasion and metastasis.And it is of important in predicting the prognosis in colorectal carcinomas.