|
|||||
|
|
| Isoline两个新代谢物的制备及其理化性质 | |
| 引用本文： | 汤俊,张勉,王峥涛,赤尾光昭,中村.Isoline两个新代谢物的制备及其理化性质[J].中国天然药物,2003,1(1):21-23. |
| 作者姓名： | 汤俊 张勉 王峥涛 赤尾光昭 中村 |
| 作者单位： | 1. 中国药科大学生药学研究室,南京,210038;日本国富山医科药科大学和汉药研究所,杉谷,2630,日本国富山市,930-0194 2. 中国药科大学生药学研究室,南京,210038 3. 日本国富山医科药科大学药学部,杉谷,2630,日本国富山市,930-0194 4. 日本国富山医科药科大学和汉药研究所,杉谷,2630,日本国富山市,930-0194 |
| 基金项目： | 国家自然科学基金杰出青年基金资助项目(No.39825129)~~ |
| 摘 要： | 目的：为进一步研究isoline的代谢和毒理，采用化学方法制备其代谢产物。方法：分别采用水解，氮氧化和脱氢化反应将isoline转化为与代谢和毒理研究相关类型的产物。结果与结论：成功地制备了五个化合物，其中两个为新化合物，其结构经UV，IR.MS和NMR分析得以鉴定。 |
| 关 键 词： | Isoline 代谢物 制备 理化性质 毒理 |
Preparation and Characterization of Two New Metabolites of Isoline |
|
| TANG Jun,ZHANG Mian,WANG Zheng-Tao,AKAO Teruaki,NAKAMURA Norio HATTORI Masao,XU Guo-Jun.Preparation and Characterization of Two New Metabolites of Isoline[J].Chinese JOurnal of Natural Medicines,2003,1(1):21-23. | |
| Authors: | TANG Jun ZHANG Mian WANG Zheng-Tao AKAO Teruaki NAKAMURA Norio HATTORI Masao XU Guo-Jun |
| Institution: | TANG Jun,ZHANG Mian,WANG Zheng-Tao,AKAO Teruaki,NAKAMURA Norio HATTORI Masao,XU Guo-Jun Department of Pharmacognosy,China Pharmaceutical University,Nanjing 210038,China Institute of Natural Medicine,Faculty of Pharmaceutical Sciences,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan |
| Abstract: | AIM: To prepare the metabolic compounds of isoline for further investigation of its metabolism and toxicology. METHODS:The improved chemical procedures involving hydrolysis, N-oxidation and dehydrogenation were used to convert isoline to the compounds of closely related structural types, which may be formed by in vivo enzyme systems. RESULT and CONCLUSION: Five compounds were successfully prepared from isoline, in which two new compounds were determined as isoline N-oxide and dehydro-isoline by UV,IR,MS and by extensive use of NMR techniques. |
| Keywords: | Isoline Metabolites Dehydrogenation Isoline N-oxide Dehydro-isoline |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |