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CD4+CD25+ regulatory T cell-mediated changes in the expression of endocytic receptors and endocytosis process of human dendritic cells |
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| Authors: | Navarrete Ana-Maria Delignat Sandrine Teillaud Jean-Luc Kaveri Srini V Lacroix-Desmazes Sébastien Bayry Jagadeesh |
| Affiliation: | a Institut National de la Santé et de la Recherche Médicale, Unité 872, Paris F-75006, France b Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Paris 6, UMR S 872, 15 rue de l’Ecole de Médicine, Paris F-75006, France c Université Paris Descartes, UMR S 872, Paris F-75006, France d International Associated Laboratory IMPACT, at National Institute of Immunohaemotology, Mumbai, Institut National de la Santé et de la Recherche Médicale, France and Indian Council of Medical Research, India |
| Abstract: | CD4+CD25+ regulatory T cells (Tregs) are known to inhibit immune responses to antigens. Since, the process of antigen uptake by dendritic cells (DC) is central to induction of immune responses, we analyzed the effect of Tregs on the expression of endocytic receptors on DC and its repercussion on antigen uptake. Our results demonstrate that Tregs down-regulate the expression and uptake of antigens via C-type lectin-like receptors CD206 and DC-SIGN, restrain the pinocytosis process of DC and augment the expression of FcγRIIB, an inhibitory Fcγ receptor the engagement of which by IgG-bound antigens leads to inhibition of DC activation. Our results thus provide an additional insight on the pertinence of strategies aimed at blocking Treg functions towards improved vaccination protocols. |
| Keywords: | CD4+CD25+ regulatory T cells Dendritic cells Vaccines Endocytic receptors |
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