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The effect of influenza vaccination on risk of acute myocardial infarction: self-controlled case-series study |
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| Authors: | Gwini Stella M Coupland Carol A C Siriwardena Aloysius N |
| Affiliation: | a DEPM Centre for Occupational and Environmental Health, Monash University, 99 Commercial Road, Melbourne, Vic 3004, Australia b Division of Primary Care, School of Community Health Sciences, Floor 13, Tower Building, University of Nottingham, Nottingham NG7 2RD, United Kingdom c Faculty of Health, Life and Social Sciences, University of Lincoln & NHS Lincolnshire, Brayford Campus, Lincoln LN6 7TS, United Kingdom |
| Abstract: | Acute myocardial infarction (AMI) peaks in winter months, partly linked to epidemic influenza. This implies that influenza vaccination may prevent some cases of AMI. This study investigated the association between influenza vaccination and AMI using the self-controlled case-series method. We identified 8180 cases of first AMI aged 40 years and over at time of diagnosis. The incidence of AMI was significantly reduced in the 60 days following vaccination (compared with the baseline period), ranging from a reduction of 32% (IRR 0.68; 95% CI 0.60-0.78) at 1-14 days after vaccination, to 18% (IRR 0.82; 95% CI 0.75-0.90) at 29-59 days after vaccination. Reductions in AMI incidence were more pronounced for early seasonal vaccinations before mid-November. |
| Keywords: | Myocardial infarction Influenza vaccination Self-controlled case series design |
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