血浆内脏脂肪素水平与冠状动脉粥样硬化程度的相关性

目的 研究血浆内脏脂肪素水平是否与冠状动脉粥样硬化严重程度存在相关性.方法 62名患者接受冠状动脉造影检查,按造影结果 分为对照组13例和冠状动脉硬化组49例,并采用Gensini积分系统评估冠状动脉粥样硬化严重程度,将冠状动脉粥样硬化组患者分为轻度和重度冠状动脉粥样硬化组二个亚组.ELISA法检测各组血浆内脏脂肪素水平,比色法检测血脂水平.结果 与对照组比较,冠状动脉粥样硬化组血浆内脏脂肪素水平显著升高;重度冠状动脉粥样硬化组血浆内脏脂肪素水平显著高于轻度冠状动脉粥样硬化组;血浆内脏脂肪素水平与冠状动脉Gensini积分呈正相关(r=0.359;P<0.01).结论 血浆内脏脂肪素水平与冠状动脉粥样硬化严重程度相关,提示内脏脂肪素可能参与了冠状动脉粥样硬化的发生发展.

Relationship Between Plasma Visfatin Level and Coronary Artery Atherosclerosis in Patients with Coronary Artery Diseases

Aim To explore the relationship between plasma visfatin level and coronary artery atherosclerosis (As) in patients with coronary artery diseases (CAD). Methods 62 causes were undergone coronary angiography and divided into control group of 13 cases and As group of 49 cases. The severity of coronary stenosis was determined by Gensini score and based on the results, the As group were classified into two sub-groups: mild and severe groups. The plasma levels of visfatin were measured by ELISA kits. Results Compared with control group, plasma level of visfatin was significantly elevated in As group. In As groups, patients with severe As have higher plasma level of visfatin than those in patients with mild As. Moreover, plasma level of visfatin was positively correlated with Gensini (r=0.359, P<0.01). Conclusions The plasma level of visfatin is closely correlated with the severity of coronary artery in CAD patients, suggesting that visfatin may be involved in the process of As.