| 艾灸对实验性类风湿关节炎滑膜细胞原癌基因 c-fos和c-myc mRNA表达的影响 |
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| 引用本文： | 余俊辉,刘旭光,余曙光,蔡美英,周昌华,赵宗蓉,张平. 艾灸对实验性类风湿关节炎滑膜细胞原癌基因 c-fos和c-myc mRNA表达的影响[J]. 西部医学, 2005, 17(2): 108-110 |
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| 作者姓名： | 余俊辉 刘旭光 余曙光 蔡美英 周昌华 赵宗蓉 张平 |
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| 作者单位： | 1. 四川大学华西基础与法医学院,免疫教研室,四川,成都,610041
2. 成都中医药大学针灸推拿学院 |
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| 基金项目： | 国家自然科学基金重大研究计划资助项目(NO:90209022). |
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| 摘 要： | 目的观察艾灸对实验性类风湿关节炎滑膜细胞原癌基因c-fos、c-myc mRNA表达的影响,初步探讨艾灸对RA滑膜细胞内分子信号传导的调控.方法在日本大耳白兔右后足踝关节部皮内注射福氏完全佐剂造模,经过艾灸治疗,通过半定量RT-PCR测定c-fos和c-myc mRNA的表达量.结果治疗组c-fos和c-myc mRNA表达量显著低于造模组(P＜0.01).结论艾灸治疗能够降低c-fos和c-myc mRNA的表达,影响生长因子信号传导系统.
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| 关 键 词： | 实验性类风湿性关节炎 c—fos c—myc 滑膜细胞 艾灸 |
| 文章编号： | 1762-3511(2005)02-0108-03 |
| 修稿时间： | 2004-11-08 |
Effects of moxibustion on the expression of protooncogene c-fos and c-myc mRNA in experimental arthritis |
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| YU Jun-hui,LIU Xu-guang,YU Shu-guang,et al.. Effects of moxibustion on the expression of protooncogene c-fos and c-myc mRNA in experimental arthritis[J]. , 2005, 17(2): 108-110 |
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| Authors: | YU Jun-hui LIU Xu-guang YU Shu-guang et al. |
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| Abstract: | Objective To investigate the role of moxibustion in rheumatoid arthritis(RA) by detecting the expression of protooncogene c-fos and c-myc mRNA in experimental arthritis rabbits. Methods The experimental rabbit model was set up by injection of complete adjuvant into right ankle joint. Rabbits were grouped randomly into three groups: normal, model and moxibustion-treatment groups. The expression of c-fos and c-myc mRNA was detected by semi-quantity RT-PCR. Results Compared with model group, the expression of c-fos and c-myc mRNA was significantly reduced in moxibustion-treatment group(P<0.01).Conclusion Moxibustion may play a protective role in RA by downregulating the expression of protooncogene c-fos and c-myc. |
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| Keywords: | Rheumatoid arthritis c-fos c-myc Synoviocytes Moxibustion |
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