相同单体核型恶性血液病二例治疗体会并文献复习

目的报道2例del（5）恶性血液病的不同治疗过程，通过文献复习探讨不同治疗方式。 方法分别采用雷利度胺及地西他滨为基础的治疗方案，观察患者的血象、临床表现及细胞遗传学的变化。 结果2例患者采用不同的治疗方案，均获得细胞遗传学缓解。 结论相同的单体核型在不同疾病具有不同的预后价值，依据指南治疗才能取得良好效果。

Treatment of hematologic malignancies with same monosomal karyotype: Report of two cases and review of the literature

ObjectiveTo assess the therapeutic effects of different regimens in two hematologic malignancy patients with del (5) and perform a review of the literature. MethodsThe changes of blood para, clinical manifestations, and cytogenetics were investigated in two patients with hematologic malignancies who were treated with lenalidomide and decitabine-based regimens, respectively. ResultsAlthough the two patients received different treatments, they both achieved cytogenetic remission. ConclusionThe same monosomal karyotype may predict different prognoses in different diseases, and treatment based on guidelines should be adopted in order to achieve good results.