| 间歇低氧小鼠血清氧化应激指标的变化及N-乙酰半胱氨酸的治疗作用 |
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| 引用本文： | 李亚男,陈锐,刘辉玉,施敏骅,刘春风. 间歇低氧小鼠血清氧化应激指标的变化及N-乙酰半胱氨酸的治疗作用[J]. 江苏医药, 2011, 37(4) |
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| 作者姓名： | 李亚男 陈锐 刘辉玉 施敏骅 刘春风 |
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| 作者单位： | 苏州大学附属第二医院呼吸病科,215004 |
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| 摘 要： | 目的观察间歇低氧(I H)小鼠血清氧化应激指标的变化情况,并探讨N-乙酰半胱氨酸(NAC)的治疗作用。方法随机将50只小鼠分为对照组(A组,20只),IH组(B组,30只),分别造模3d、1周、2周、3周、4周;另设IH4周+NAC组(C组,6只)。检测各组小鼠血清超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-PX)表达水平。结果与A组同期比较,B组MDA表达均升高(P<0.05);造模1周后,SOD、GSH-PX表达均降低(P<0.05)。随低氧时间的延长,B组MDA逐渐升高,SOD、GSH-PX逐渐降低(P<0.05)。与B组比较,C组MDA降低,SOD、GSH-PX升高(P<0.05)。结论 IH可导致机体氧化应激水平增加,而NAC治疗能够改善IH导致的氧化应激反应。
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| 关 键 词： | 间歇低氧 N-乙酰半胱氨酸 超氧化物歧化酶 丙二醛 谷胱甘肽过氧化物酶 |
The changes of serum oxidative stress indexes of mice exposed to intermittent hypoxia and the therapeutical effect of N-acetylcysteine |
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| LI Yanan,CHEN Rui,LIU Huiyu,et al.. The changes of serum oxidative stress indexes of mice exposed to intermittent hypoxia and the therapeutical effect of N-acetylcysteine[J]. Jiangsu Medical Journal, 2011, 37(4) |
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| Authors: | LI Yanan CHEN Rui LIU Huiyu et al. |
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| Affiliation: | LI Yanan,CHEN Rui,LIU Huiyu,et al.Departmemt of Respiratory Diseases,Sleeping Center,Second Affiliated Hospital,Soochow University,Suzhou 215004,CHINA |
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| Abstract: | Objective To investigate the changes of serum oxidative stress indexs of mice exposed to intermittent hypoxia(IH) and the therapeutical effect of N-acetylcysteine(NAC).MethodsFifty mice were randomly divided into control group(group A,20 mice) and IH group(group B,30 mice),models of which were respectively established for 3 days,1 week,2 weeks,3 weeks and 4 weeks.And IH 4 weeks plus NAC treatment group(group C,6 mice) was set up.Serum levels of superoxide dismutase(SOD),malondialdehyde(MDA) and glutathione ... |
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| Keywords: | Intermittent hypoxia N-acetylcystein Superoxide dismutase Malondialdehyde Glutathione peroxidase |
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