Lack of association of CCR gene polymorphisms and left ventricular hypertrophy in essential hypertension |
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| Authors: | Mettimano M Specchia M L La Torre G Bruno A Ricciardi G Romano-Spica V Savi L |
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| Institution: | Hypertension Center of the Catholic University Medical School, Rome, Italy. mamettim@tin.it |
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| Abstract: | Left ventricular hypertrophy (LVH) is a major determinant of heart damage. Scientific evidence suggests the influence of genetic factors, but these have yet to be completely clarified. This study investigates a possible relationship between LVH and two chemokine receptor (CCR) gene polymorphisms: CCR5delta32 and CCR264I. Essential hypertensive out-patients (n=118, grade I-II, age 27-54) were recruited from the Catholic University Hypertension Centre. For each subject, clinical data on office blood pressure and M-mode/2D echocardiography were collected. Statistical analysis did not show a significant association between the CCR polymorphisms and LVH in the study population. |
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