Emotional processing in Parkinson's disease: a systematic review |
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| Authors: | Péron Julie Dondaine Thibaut Le Jeune Florence Grandjean Didier Vérin Marc |
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| Affiliation: | 1. Behavior and Basal Ganglia Research Unit (EM 425), University of Rennes 1, H?pital Pontchaillou, CHU de Rennes, Rennes, France;2. Neurology Unit, H?pital Pontchaillou, CHU de Rennes, Rennes, France;3. Neuroscience of Emotion and Affective Dynamics Laboratory, Department of Psychology and Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland;4. Nuclear Medicine Department, Eugène Marquis AntiCancer Centre, Rennes, France |
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| Abstract: | ![]()
Parkinson's disease provides a useful model for studying the neural substrates of emotional processing. The striato-thalamo-cortical circuits, like the mesolimbic dopamine system that modulates their function, are thought to be involved in emotional processing. As Parkinson's disease is histopathologically characterized by the selective, progressive, and chronic degeneration of the nigrostriatal and mesocorticolimbic dopamine systems, it can therefore serve as a model for assessing the functional role of these circuits in humans. In the present review, we begin by providing a synopsis of the emotional disturbances observed in Parkinson's disease. We then discuss the functional roles of the striato-thalamo-cortical and mesolimbic circuits, ending with the conclusion that both these pathways are indeed involved in emotional processing. |
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| Keywords: | amygdala basal ganglia emotion Parkinson's disease |
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