系统性红斑狼疮患者血清白细胞介素-10、白细胞介素-18的表达及意义

目的探讨系统性红斑狼疮（SLE）患者血清中自细胞介素10（IL-10）和白细胞介素18（IL-18）的表达及其临床意义。方法71例SLE患者按SLE活动性指数积分分为活动组（51例）和非活动组（20例），另取同期健康体检者30例为对照组，采用双抗体夹心酶联免疫吸附试验检测三组患者血清IL-10、IL-18的水平。结果活动组IL-10和IL-18水平分别为（49．4±12．2）ng/L、（423．7±40．8）ng／L明显高于非活动组（20．3±8．7）ng／L、（241．6±29．1）ng／L和对照组（13．2±4．8）、（150．3±21．6）ng／L]（均P〈0．01）。结论IL-10、IL-18的表达水平和SLE的活动度有关，检测IL-10、IL-18对SLE病情的判断有一定的价值。

Serum Level of interleukin-10 and interleukin-18 in patients with systemic lupus erythematosus and its clinical significance

Objective To investigate the serum level of interleukin-10(IL-10)and interleukin-18(IL-18)and its clinical significance in patients with systemic lupus erythematosus(SLE).Methods The serum level of IL-10and IL-18 of 71 SLE patients(the active group 51 patients and stable group 20 patients)and 30 normal controls were measured by ELISA.Results The serum IL-10 and IL-18 level of the active SLE patients(49.4±12.2)、(423.7+40.8)ng/L]were significantly higher than that of the stable SLE patients(20.3±8.7);(241.6 ±29.1)ng/L]and control(13.2±4.8);(150.3±21.6)ng/L](all P＜0.01).Conclusion IL-10 and IL-18 may play an important role in the pathogenesis of SLE and may be of useful clinical value in judsing SLE disease activity and its treatment.