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Spontaneous regression of optic pathways gliomas in three patients with neurofibromatosis type I and critical review of the literature
Authors:Manolo Piccirilli  Jacopo Lenzi  Catia Delfinis  Guido Trasimeni  Maurizio Salvati  Antonino Raco
Affiliation:(1) Department of Neurosurgical Sciences, Neurosurgery, University of Rome, La Sapienza, Rome, Italy;(2) Department of Neuroradiology, Sant’Andrea Hospital, Rome, Italy;(3) Neurosurgery, INM Neuromed, Pozzilli (IS), Italy;(4) Neurochirurgia 1, Viale del Policlinico, 155, 00185 Rome, Italy
Abstract:Case reports The authors report their experience about three children (two girls, one boy; average age 1.6 years) with a spontaneous regression of optic gliomas. All of them had a previous diagnosis of neurofibromatosis type 1 (NF 1). None of them underwent surgery or biopsy nor received chemotherapy or radiotherapy. The complete regression was documented by MRI scans performed during a mean follow-up of 6.3 years.Literature review Moreover, the authors analyze the features of the 16 cases previously reported in English literature of spontaneously regressed optic gliomas with an overview of the different therapeutic strategies. The knowledge that this kind of tumor, particularly in young patients, may regress is important in the decision of the best therapeutic approach.
Keywords:Optic gliomas  Magnetic resonance imaging  Neurofibromatosis type I
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