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| 肾必宁对大鼠系膜增生性肾小球肾炎肾小球细胞凋亡及bax、bcl-2表达的影响 | |
| 引用本文： | 耑冰,丁樱,吴力群. 肾必宁对大鼠系膜增生性肾小球肾炎肾小球细胞凋亡及bax、bcl-2表达的影响[J]. 中国中西医结合肾病杂志, 2003, 4(6): 316-318 |
| 作者姓名： | 耑冰 丁樱 吴力群 |
| 作者单位： | 1. 成都中医药大学,成都,610075 2. 河南中医学院,郑州,450003 |
| 摘 要： | 目的：探讨中成药肾必宁对慢性血清病性系膜增生性肾炎肾小球细胞凋亡与调控基因bax、bcl—2表达的影哨。方法：应用大鼠慢性血清病性系膜增生性肾炎模型；造模第4周起，灌服中成药肾必宁，以等量生理盐水为对照；24h定量测定尿蛋白；TUNEL法检测实验大鼠肾小球细胞凋亡；免疫组化SABC法观察bax、bcl—2表达的改变。结果：肾必宁治疗组肾小球细胞凋亡率较病理组升高(P＜0．01)，bax表达增强(P＜0．01)，bcl—2表达下降(P＜0.01)。结论：肾必宁可能通过影哨凋亡调控基因bax、bcl—2的表达，诱导肾小球细胞凋亡，进而抑制系膜增生性肾小球肾炎系膜细胞增殖。 |
| 关 键 词： | 肾必宁 大鼠 系膜增生性肾小球肾炎 肾小球细胞凋亡 bax bcl—2 基因表达 中成药 |
| 修稿时间： | 2002-07-26 |
Effects of Shenbining on Apoptosis and Experssion of Bax and Bcl-2 in the Kidney of Mesangial Proliferative Glomerulonephritis |
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| ZHUAN Bing,DING Ying,WU Liqun Chengdu University of Traditional Chinese Medicine,Chengdu. Effects of Shenbining on Apoptosis and Experssion of Bax and Bcl-2 in the Kidney of Mesangial Proliferative Glomerulonephritis[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2003, 4(6): 316-318 | |
| Authors: | ZHUAN Bing DING Ying WU Liqun Chengdu University of Traditional Chinese Medicine Chengdu |
| Abstract: | Objective:To investgate the influence of Shenbining(SBN) in the apoptosis in Mesangial proliferative glomerulonephritis. Methods:Shenbining was given to rat models of mesangial proliferative glomerulonephritis and saline taken as a control.Using the method of TUNEL to study the apoptosis in glomeruli and immunohisto chemistry SABC to investigate the expression of bax and bcl-2 in renal tissue.Results:The apoptosis rate and the expression of bax ascend while the expression of bcl-2 descends in treated group.Conclusion:Shenbining may affect the expression of bax and bcl-2 and induce to apoptosis in Mesangial proliferative glomerulonephritis. |
| Keywords: | Chinese medcine Glomerulonephritis Apoptosis |
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