| 炭疽杆菌表面四糖抗原全合成的研究进展 |
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| 引用本文： | 黄蕾,许克寒,吴俊琪,姚阔,俞世冲,吴秋业.炭疽杆菌表面四糖抗原全合成的研究进展[J].药学实践杂志,2015,33(6):481-485,569. |
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| 作者姓名： | 黄蕾 许克寒 吴俊琪 姚阔 俞世冲 吴秋业 |
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| 作者单位： | 第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433,第二军医大学药学院有机化学教研室, 上海 200433 |
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| 基金项目： | 国家科技重大专项(No.2012ZX09502001-005,2011ZXJ09201-012);国家自然科学基金青年项目(No.21202200);第二军医大学药学院大学生科研训练计划项目 |
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| 摘 要： | 炭疽是由炭疽杆菌引起的人畜共患的传染病。炭疽杆菌属于需氧芽孢杆菌属,为G+菌,其病原体是芽孢。炭疽芽孢最外层含有特定结构的四糖抗原,可用于制备糖缀合物疫苗,诱导免疫反应。综述近10年来文献报道对炭疽四糖化学合成的研究进展,并结合国内外最新研究成果介绍各条制备路线,比较各种方法的主要优缺点。
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| 关 键 词： | 炭疽四糖 糖基化 化学合成 |
| 收稿时间： | 4/3/2014 12:00:00 AM |
| 修稿时间： | 2014/7/11 0:00:00 |
Research progress in the synthesis of antigen Bacillus anthracis tetrasaccharide |
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| HUANG Lei,XU Kehan,WU Junqi,YAO Kuo,YU Shichong and WU Qiuye.Research progress in the synthesis of antigen Bacillus anthracis tetrasaccharide[J].The Journal of Pharmaceutical Practice,2015,33(6):481-485,569. |
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| Authors: | HUANG Lei XU Kehan WU Junqi YAO Kuo YU Shichong and WU Qiuye |
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| Institution: | Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective Anthrax is an anthropozoonosis caused by the bacterium Bacillus anthracis. Bacillus anthracis is an aerobic, spore-forming, rod-shaped bacterium, which infects human through ingestion or inhalation of the spores. The exosporium of spores of Bacillus anthracis contains tetrasaccharide antigen with specific chemical structure, which can be used in preparation of glycoconjugates vaccines, inducing an immune response. This paper reviewed articles in the last decade that reported research advances in chemical synthesis of anthrax tetrasaccharide, presented the methods for synthesis, and compared the advantages and limitations among different methods. |
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| Keywords: | anthrax tetrasaccharide glycosylation chemosynthesis |
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