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Identification and determination of 2-thiothiazolidine-4-carboxylic acid in urine of workers exposed to carbon disulfide |
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| Authors: | R. van Doorn L. P. C. Delbressine Ch. -M. Leijdekkers P. G. Vertin P. Th. Henderson |
| Affiliation: | (1) Departments of Pharmacology and Toxicology, University of Nijmegen, G. Grooteplein Noord 21, Nijmegen, The Netherlands;(2) Department of Dermatology, University of Nijmegen, G. Grooteplein Noord 21, Nijmegen, The Netherlands;(3) Department of Social Medicine, University of Nijmegen, G. Grooteplein Noord 21, Nijmegen, The Netherlands |
| Abstract: | A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method allowed detection of TTCA concentrations in urine as low as 5 × 10–7 M.No TTCA was detected in urine of workers occupationally exposed to organic solvents other than CS2. High concentrations of TTCA (upto 32×10–5 M) were shown to be present in urine of spinners exposed to CS2 concentrations of approximately 100 mg/m3. It is suggested that the assay of urinary TTCA is suitable for detection of occupational exposure to CS2. |
| Keywords: | Carbon disulfide Viscose rayon industry CS2-metabolite Biological monitoring 2-Thiothiazolidine-4-carboxylic acid HPLC |
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