盐酸戊乙奎醚在复合全身麻醉中的应用价值研究

目的：探讨盐酸戊乙奎醚在全身麻醉中的应用价值。方法：61例患者均选自2008—2011年本院麻醉科开展全麻手术者，将患者随机分为观察组32例和对照组29例，对照组采用阿托品麻醉，观察组采用盐酸戊乙奎醚麻醉。观察静卧10min后，注药后1、3、5、10和20min心率（HR）和平均动脉压（MAP）变化。运用视觉模拟评分法（visualanaloguescale，VAS）测定口干程度并记录给药前、给药后20min、术后1h和苏醒后口干程度。结果：观察组患者麻醉3min起各时间段的HR均较对照组麻醉后低（P〈0．05）；观察组患者麻醉5min后的MAP均较对照组麻醉后低（P〈0．05）。观察组患者的VAS评价结果明显优于对照组，差异具有统计学意义（P〈0．05）。结论：盐酸戊乙奎醚能有效、快速地减轻抗胆碱药的心血管副作用，有利于患者平稳进入麻醉，在麻醉后恢复过程中也能大大降低过多分泌物对拔管的影响。

The Research of the Value for the Application of Penehyclidine Hydrochloride in General Anesthesia

Objective： To investigate the application of penehyclidine hydrochloride be used in generu] anesthesia.Method： 61 patients who carried out of anesthesia general anesthesia from 2008 to 2011 in our hospital were chosen, and they were randomly divided into treatment group （ 29 cases ） and control group （ 32 cases ） .The treatment group was taken with atropine anesthesia, and the observation group was treated with hydrochloric acid penehyclidine anesthesia.The changes of heart rate （ HR ） and mean arterial pressure （ MAP ） 1, 3, 5, 10 and 20 min after injection 10 min of repose were observed. The use of visual analogue scales （ visual analogue scale, VAS ） for the determination of the extent of dry mouth and recorded the extent of dry mouth 20 min after taking drugs, 1 h after surgery and after waking.Result： The HR after taking anesthesia for 3 min was lower compared with the use of atropine （ P〈0.05 ） . The MAP anesthesia after 5 min in the observation group was lower compared with the control group after anesthesia （P〈0.05） .The VAS evaluation results of the observation group were significantly better than the control group patients, the difference was statistically significant （ P〈0.05 ） .Conclusion： Penehyclidine hydrochloride was effective, fast to reduce the cardiovascular side effects of anticholinergic drugs.And it is beneficial to patients with stable access to anesthesia.In the post anesthesia, recovery process can greatly reduce the impact of excessive secretion of the extubation.