珍柏汤保留灌肠对溃疡性结肠炎患者肛门直肠动力学的影响

目的：观察珍柏汤保留灌肠对溃疡性结肠炎患者肛门直肠动力学的影响。方法：选择中医辨证属湿热型溃疡性结肠炎患者41例为UC组，予经验方珍柏汤改良保留灌肠法治疗，治疗前后分别采用多导单囊肛门直肠功能测定仪检测肛门括约肌压力、直肠感觉闽值及肛门直肠抑制反射，并设30例正常人为对照组进行比较。结果：UC组患者肛门括约肌压力正常，治疗前直肠感知阈值、排便阈值、疼痛阈值、引起直肠肛门抑制反射时最小充气量均低于对照组，差异有统计学意义（P〈0．01）；治疗后，UC组直肠感知阈值、排便阈值、疼痛阈值、引起直肠肛门抑制反射时最小充气量均明显提高，差异有统计学意义（P〈O．01）。结论：珍柏汤改良保留灌肠能使大部分溃疡性结肠炎患者直肠敏感性降低，改善临床症状。

Effect on Anorectal Motility in Ulcerative Colitis Patients by Retention Enema with Zhen Bo Decoction

Objective：To observe the change of anorectal motility in ulcerative colitis（UC） patients by retention enema with Zhen Bo decoction.Methods： There were 41 cases with moist heat UC ,which were cured by improved enema whith the Zhen Bo decoction. The anorectal sphincteric pressure, anorectal sensory thresholds and anorectal inhibitory reflex were examined by means of multi-channel and single-balloon anorectal function detector, comparing with 30 normal subjects. Results： In patients with UC during active period, the anorectal sphincteric pressure was similar to normal subjects; the rectal sensitivity volume thresholds, defecation volume thresholds, rectal maximum tolerable volume thresholds and the minimum relaxation volume to elicit the anorectal inhibitory reflex were much lower than those in normal subjects （P〈0.01）; the anorectal sensitivity in UC patients increased （P〈0.01）. Conclusion： Retention enema of Zhen Bo decoction can decrease anorectal sensitivity of most UC patients to relieve clinical symptoms.