Preservation of the ischaemic canine kidney with inosine

Summary Direct intra-renal perfusion of inosine was found to protect the canine kidney from 90 min of warm is chaemia.Significantly lower (P<0.01) serum creatinine levels were found 24 and 72 h post-operatively in an inosine treated group (N=12) when compared to a control group (N=5).Histological examination of the pre-treated kidneys confirmed the protective effect of inosine.