| 介导 p53 基因转移的重组体腺病毒对人肺癌细胞的抑制作用 |
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| 引用本文： | 邢嵘,林晨,牟巨伟,程金科,张雪艳,吴旻. 介导 p53 基因转移的重组体腺病毒对人肺癌细胞的抑制作用[J]. 大连医科大学学报, 2000, 22(2): 84-87 |
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| 作者姓名： | 邢嵘 林晨 牟巨伟 程金科 张雪艳 吴旻 |
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| 作者单位： | 大连医科大学病理生理学教研室,辽宁,大连,116027;中国医学科学院中国协和医科大学肿瘤研究所细胞生物室分子肿瘤学重点实验室,北京,100021 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | ｐ５３基因突变是肿瘤发生中的多发事件,导入野生型ｐ５３基因能抑制肿瘤细胞的生长。通过腺病毒载体介导。将野生型ｐ５３基因转导到人肺腺癌细胞系（ＧＬＣ－８２）中,证实对肺腺癌细胞生长具有明显的抑制作用,换制率达６１％。
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| 关 键 词： | p53基因 腺病毒载体 人肺腺癌细胞 肿瘤基因治疗 |
| 文章编号： | 1000-5676(2000)02-0084-04 |
| 修稿时间： | 2000-03-06 |
The growth suppression of human lung adenocarcinoma cell by the introduction of the Wild-type p53 gene via a recombinant abenovirus |
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| XING Rong,LIN Chen,CHENG Jin-ke. The growth suppression of human lung adenocarcinoma cell by the introduction of the Wild-type p53 gene via a recombinant abenovirus[J]. Journal of Dalian Medical University, 2000, 22(2): 84-87 |
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| Authors: | XING Rong LIN Chen CHENG Jin-ke |
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| Affiliation: | XING Rong(Department of Pathophysiology, Dalian Medical University, Dalian 116027, China)LIN Chen,CHENG Jin-ke(Department of Cell Biology and National Laboratory of Molecular Oncology, Caccer Institute, Chiaese Academy of Medical Science, Peking UnionMedical College, Beijing 100021, China) |
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| Abstract: | In our research,the wild-type p53 gene was transferred into human lung adenocarcinoma cell line(GLC-82)and reduced the growth of GLC-82 cells in vivo and in vitr(the inhibiting rate:61% and 42%).The other results demonstrated that adenovirus-mediated transfer and espression of the wild-type p53 in GLC-82 lacking ghe p53 gene resulted in GLC-82 cells apoptosis which was indicated by FCM and DNA fragment analysis.These results can offer yome scientific evidences for use of the wild-type. p53 gene to tumor gene therapy. [WT5HZ] |
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| Keywords: | p53 adenovirus vector GLC-82 cell line tumor gene therapy |
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