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| 乙型脑炎重组痘苗病毒J3免疫性的研究 | |
| 引用本文： | 刘启富 娄元梅. 乙型脑炎重组痘苗病毒J3免疫性的研究[J]. 免疫学杂志, 1997, 13(2): 90-92 |
| 作者姓名： | 刘启富 娄元梅 |
| 作者单位： | 第三军医大学微生物学教研室 |
| 摘 要： | 用含有日本脑炎病毒（ＪＥＶ）结构蛋白ＰｒＭ、Ｅ和非结构蛋白ＮＳ１、ＮＳ２Ａ基因的重组痘苗病毒Ｊ３免疫家兔，能较快地诱生抗ＪＥＶ抗体，其滴度可随免疫次数的增加和免疫时间的延长而增高。此抗血清可被动保护不同毒株ＪＥＶ的致死性攻击，该保护作用与其中抗体和血凝抑制抗体有关。 |
| 关 键 词： | 乙型脑炎 重组痘苗病毒J3 免疫原性 |
IMMUNITY OF A RECOMBINANT VACCINIA VIRUS J 3 EXPRESSING JAPANESE ENCEPHALITIS VIRUS ANTIGENS |
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| Liu Qifu,Lou Yuanmei,Zhu Dezhong,Jian Rei. IMMUNITY OF A RECOMBINANT VACCINIA VIRUS J 3 EXPRESSING JAPANESE ENCEPHALITIS VIRUS ANTIGENS[J]. Immunological Journal, 1997, 13(2): 90-92 | |
| Authors: | Liu Qifu Lou Yuanmei Zhu Dezhong Jian Rei |
| Abstract: | Immunization of rabbits with a recombinant vaccinia virus J 3 containing PrM,E,NS1, NS2A genes of japanese encephalitis virus(JEV) could produce rapidly specific antisera against JEV and the titres of antibodies increased with immunization times. Passive protective assay demonstrated that the antisera had an excellent protective efficacy in mice challenged with three different JEV strains. |
| Keywords: | Recombinant vaccinia virus J 3 Japanese encephalitis virus Immunogenicity Passive protection |
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