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| 异丙酚预处理对大鼠创伤脑组织的保护作用 | |
| 引用本文： | 荣健,叶升,吴静波. 异丙酚预处理对大鼠创伤脑组织的保护作用[J]. 中国医药指南, 2011, 9(13): 205-206 |
| 作者姓名： | 荣健 叶升 吴静波 |
| 作者单位： | 1. 广东省中山大学附属第一医院,广东,广州,510080 2. 广东省药学院附属第一医院,广东,广州,510080 |
| 摘 要： | 目的探讨异丙酚预处理对大鼠创伤脑组织神经元特异性烯醇化酶(NSE)含量的影响,评价异丙酚的脑保护作用。方法 25只SD大鼠,随机分为假手术组(A组5只)、单纯脑创伤组(B组10只)和创伤前2h异丙酚预处理组(C组10只),C组动物在创伤前腹腔注射异丙酚100mg/kg,采用SD大鼠局灶性创伤性脑损伤模型,于脑创伤后24h评估并记录动物的神经行为学评分,取大鼠脑组织行NSE测定。结果异丙酚预处理组神经行为学评分较单纯脑创伤组高(P<0.05),异丙酚预处理组脑组织中NSE含量明显低于单纯脑创伤组(P<0.05)。结论异丙酚可以降低脑创伤大鼠脑组织神经元特异性烯醇化酶的含量,减轻神经损害,创伤前2h异丙酚预处理可以改善大鼠脑创伤后的神经行为学评分,有明显的脑保护作用。 |
| 关 键 词： | 异丙酚 脑创伤 神经元特异性烯醇化酶 |
Effects of Propofol Pretreatment on NSE of Brain Tissues with Traumatic Brain Injury in Rats |
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| RONG Jian,YE Sheng,WU Ying-bo. Effects of Propofol Pretreatment on NSE of Brain Tissues with Traumatic Brain Injury in Rats[J]. Guide of China Medicine, 2011, 9(13): 205-206 | |
| Authors: | RONG Jian YE Sheng WU Ying-bo |
| Affiliation: | RONG Jian1,YE Sheng1,WU Jing-bo2(1 The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China,2 The First Affiliated Hospital of Guangdong pharmaceutical school,China) |
| Abstract: | Objective To study the effects of propofol pretreatment on NSE of brain tissues with traumatic brain injury in rats,and to evaluate the brain-protective effects of propofol.Methods 25 SD rats were randomly divided into 3 groups: sham operation group(group A,n=5);single traumatic brain injury group(group B,n=10);propofol pretreatment at 2h before traumatic brain injury group(groupC,n=10).Propofol(100mg/kg) was given intraperitoneally before ischemia to group C.24h after traumatic brain injury rats through th... |
| Keywords: | Propofol Traumatic brain injury Neuron-specific enolase |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |