Successfully treated bronchopulmonary oxalosis caused by Aspergillus tubingensis in a non-neutropenic patient: A case report and review of the literature |
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| Affiliation: | 1. Department of Pulmonary Medicine, Saitama City Hospital, 2460 Mimuro, Midori-ku, Saitama City, Saitama, 336-8522, Japan;2. Department of General Thoracic Surgery, Saitama City Hospital, 2460 Mimuro, Midori-ku, Saitama City, Saitama, 336-8522, Japan;3. Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 60-8673, Japan;1. Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China;2. Department of Blood Transfusion, Affiliated Hospital of Zunyi Medical University, Zunyi, China;3. School of Laboratory Medicine, Zunyi Medical University, Zunyi, China;1. Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan;2. Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan;3. Department of Digestive Tract Internal Medicine, Tokyo General Hospital, Tokyo, Japan;4. Department of Clinical Laboratory, Tokyo General Hospital, Tokyo, Japan;1. Department of Internal Medicine, Groupe Hospitalier Sud Ile de France, 77000, Melun, France;2. Department of Infectious Diseases, Nord Franche-Comté Hospital, 90400, Trévenans, France;3. Department of Clinical Immunopathology, Saint-Louis Hospital, University of Paris, 75010, Paris, France;1. Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan;2. Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;3. Department of Respiratory Medicine, Nagasaki Aino Memorial Hospital, Nagasaki, Japan;4. Department of Otolaryngology-Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;5. Department of Radiology, Nagasaki University Hospital, Nagasaki, Japan;6. Department of Neurology and Strokology, Nagasaki University Hospital, Nagasaki, Japan |
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| Abstract: | Pulmonary oxalosis can be fatal, and Aspergillus tubingensis is commonly resistant to azoles in Japan. We report a case of bronchopulmonary oxalosis caused by A. tubingensis in a non-neutropenic patient who was successfully treated with voriconazole monotherapy. The susceptibility of the isolates to voriconazole and the effective elimination of contagious necrotic tissue by expectoration seemed to be two major factors contributing to the patient's survival. According to the literature review, pulmonary oxalosis is associated with a high mortality rate over a short term. An exploration of detailed information about the genomic characteristics and drug susceptibility of Aspergillus isolates is important for the development of treatment strategies for this life-threatening disease. |
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| Keywords: | Non-neutropenic Case report |
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