冠心病危险因素与冠状动脉病变程度的关系

目的探讨冠心病危险因素与冠状动脉病变程度的关系。方法对近１０年来疑诊冠心病,选择性冠状动脉造影的４４６例住院病例,进行了危险因素调查。结果冠状动脉积分与病人年龄、吸烟量、吸烟年限、血浆总胆固醇和甘油三酯水平、糖尿病病程、动脉血压、高血压病程呈明显的正相关（ｒ＝０．１２９６～０．２７０２,Ｐ＝０．００８３～０．０００１）。经多元回归分析证实,冠状动脉病变程度与年龄、吸烟量、血浆总胆固醇和甘油三酯水平、糖尿病病程关系最为密切（Ｆ＝２．３１３０～１９．２１６５,Ｐ＝０．１２９１～０．００１）。Ｌｏｇｉｓｔｉｃ回归分析示,年龄、吸烟量、血浆总胆固醇水平、糖尿病病程为冠心病独立危险因素（ＯＲ＝１．０２～１．２３,Ｐ＝０．０４０６～０．０００１）。结论高龄、吸烟、高脂血症,糖尿病对冠心病及其病变程度具有重要作用,这一结果与以往文献报导有所不同。

Relationship between the risk factors of coronary artery disease and the severity of coronary artery lesions

OBJECTIVE: To investigate the relationship between the risk factors of coronary artery disease and the severity of the coronary artery lesions. METHODS: A total of 446 consecutivey admitted patients were studied retrospectively. All patients suspected to have coronary artery disease and underwent a selective coronary angiography and a survey of risk factors during the hospitalization. RESULTS: Through Logistic regression analysis, advanced age, smoking, hyperlipidemia and course of diabetes mellitus were confirmed to be independent risk factors for coronary artery disease (OR = 1.02-1.23, P = 0.0406-0.0001). A significant correlation (F = 2.3130-19.2165, P = 0.1291-0.0001) between the severity of the coronary artery lesions and the age, the number of cigarettes in a day, the level of plasma lipids and the course of diabetes mellitus of the patients was found from the multiple regression analysis. CONCLUSIONS: Not only the development but also the severity of the coronary artery lesions is affected by the risk factors of advanced age, smoking, hyperlipidemia, and diabetes mellitus.