Synthesis and pharmacological effect of substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides |
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| Authors: | S S Daoud S A Osman M A Karrar |
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| Affiliation: | Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan. |
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| Abstract: | ![]()
Substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides were prepared by treating the corresponding amino alcohols with thionyl chloride. Since these compounds are considered to be monofunctional 2-haloalkylamine type agents, they were tested for possible alpha-adrenergic blocking activity using the rat anococcygeus muscle. The pharmacological action of this series of compounds is discussed. |
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