黏膜下注射塞替派对非肌层侵犯膀胱癌术后复发的影响

目的 探讨黏膜下注射塞替派对非肌层侵犯膀胱癌术后复发的疗效.方法 选择经病理检查确诊为非肌层侵犯膀胱癌患者66例,随机分为注射组和常规组,各33例.注射组:先在膀胱镜下将塞替派注射到肿瘤基底部和膀胱黏膜下,30 min后行经尿道等离子双极膀胱肿瘤切除术(PKRBt),术后1周起用卡介茁(BCG)27 mg定期行经尿道膀胱灌注;常规组:PKRBt+BCG灌注.结果 随访12～36个月,平均24个月.随访期内注射组肿瘤复发5例,复发率15.2%;常规组复发9例,复发率27.3%,两组肿瘤复发率比较差异有统计学意义(P<0.05).结论 黏膜下注射塞替派、PKRBt、BCG灌注联合治疗非肌层侵犯膀胱癌具有简单易行、安全、不良反应少、费用低等优点,为有效降低非肌层侵犯膀胱癌术后复发的实用方法.

Submucosal injection of thiotepa for the prevention of recurrence of superficial bladder cancer

Objective To assess the efficacy of submucosal injection of thiotepa for the prevention of recurrence of superficial bladder cancer. Methods Sixty-six patients with superficial bladder cancer were chosen, they were randomly divided into injection group(33 cases)and control group(33 cases). In injection group, 33 patients had submucosal injection of thiotepa, after 30 minutes resection of bladder tumor were treated by PKRBt, after one week, they were given perfusion 27 mg BCG. In control group, 33 patients after the PKRBt were given perfusion BCG. Results The recurrence rate in injection group was 15.2%, and that of the control group was 27.3%. There was significant difference between the twO group (P<0.05). Con-clusions The submucosal injection of thiotepa , PKRBt and perfusion BCG could prevent tumor recur-rence,it has the following advantage,such as simple , safe, less side effect ,more economical. The submu-cosal injection is a practical method to prevent tumor recurrence and is worth popularizing.