| 急性淋巴细胞性白血病细胞及其骨髓基质细胞粘附分子表达和粘附行为的探讨 |
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| 引用本文： | 王江方,张学光,张毅,郑列琳,刘征辉,夏学鸣,茅子均. 急性淋巴细胞性白血病细胞及其骨髓基质细胞粘附分子表达和粘附行为的探讨[J]. 中国免疫学杂志, 1996, 0(5) |
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| 作者姓名： | 王江方 张学光 张毅 郑列琳 刘征辉 夏学鸣 茅子均 |
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| 作者单位： | 苏州医学院免疫研究室，苏州医学院血液科 |
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| 摘 要： | 分析了５８例急性淋巴细胞性白血病（ＡＬＬ）患者和１０例正常人骨髓单个核细胞及其骨髓基质细胞上粘附分子的表达。发现与正常人相比，白血病细胞上表达的ＣＤ１１ａ、ＣＤ１１ｂ、ＣＤ１８、ＣＤ３４、ＣＤ４４、ＣＤ４９ｄ和基质细胞上表达的ＣＤ５４，ＣＤ４９ｂ均有显著性改变（明显下降或显著增高）；同时，来自ＡＬＬ的基质细胞在粘附分子表达和粘附行为上亦不同于正常骨髓基质细胞，认为粘附分子的异常表达可能参与了ＡＬＬ的发病机制。
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| 关 键 词： | 急性淋巴细胞性白血病，粘附分子，基质细胞 |
STUDY OF THE ADHESION MOLECULE EXPRESSION ON TUMOR CELLS AND THEIR ADHESIVE BEHAVIOR IN ACUTE LYMPHOBLASTIC LEUKEMIA |
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| Wang Jiangfang,Zhang Xueguang,Zhang Yi et al.. STUDY OF THE ADHESION MOLECULE EXPRESSION ON TUMOR CELLS AND THEIR ADHESIVE BEHAVIOR IN ACUTE LYMPHOBLASTIC LEUKEMIA[J]. Chinese Journal of Immunology, 1996, 0(5) |
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| Authors: | Wang Jiangfang Zhang Xueguang Zhang Yi et al. |
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| Abstract: | The expression of adhesion molecules on bone marrow mononuclear cells (MNC) and stromal cells in 58 cases of acute lymphoblastic leukemia (ALL) and 10 normal donors was analysed.It was found that compared with normal controls,the expression of CD11a,CD11b,CD18,CD54,CD44,CD49d on tumor cells and CD54,CD49b on ALL stromal cells is abnormal (markedly decreased or increased ).The adhesion moloecule expression and their adhesive behaviour of ALL stromal cells is also different from that of the normal stromal cells.Therefore,it was thought that the abnormal expression of adhesion molecules may be involved in the pathogenesis of ALL. |
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| Keywords: | Acute lymphoblastic leukemia Adhesion molecule Stromal cell |
| 本文献已被 CNKI 等数据库收录！ |
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