XRCC1 Arg399Gln 基因多态性与鼻咽癌易感性的 Meta 分析

目的：系统评价 DNA 修复 X 射线损伤修复的交叉互补基因（XRCC1）Arg399Gln 基因多态性与鼻咽癌的遗传易感性。方法检索中国医学文献数据库及 PubMed 数据库，得出 Arg399Gln 基因多态性与鼻咽癌遗传易感性的病例‐对照研究。运用 Review Manager 5．0及 Stata12．0软件对各研究数据进行统计分析，并对文献发表偏倚、结果数据的可靠性进行评价。采取固定效应模型或随机效应模型，以合并 OR 值及相应95％ CI 评估 Arg399Gln 多态与鼻咽癌的遗传易感性。结果399Gln 等位基因与399Arg 相比，合并 OR 值及95％ CI 分别为1．14（1．04～1．26），经异质性检验，I2＝32％，PHet ＝0．18。隐性模型及共显性模型下合并 OR 值及95％ CI 分别为1．30（1．04～1．63）、1．37（1．09～1．72），经异质性检验两种模型下均不存在明显异质性，统计分析 I2和相应 PHet分别为（I2＝0，PHet ＝1．00）；（I2＝0，PHet ＝0．96）。结论 XRCC1基因 Arg399Gln 多态性与鼻咽癌的遗传易感性密切相关，399Gln 等位基因可能是亚洲人群鼻咽癌发病的危险遗传因素。

Meta analysis of association between XRCC1 Arg399Gln and nasopharyngeal carcinoma susceptibility

Objective To evaluate the association between SNP 399 in X‐ray cross‐complementing group 1 (XRCC1) and na‐sopharyngeal carcinoma susceptibility .Methods The case‐control studies on the association between SNP 399 in XRCC1 (X‐ray cross‐complementing group 1) and nasopharyngeal carcinoma susceptibility were collected by CBM disc and Pubmed .Various re‐search and statistical analysis were used by Stata12 .0 and Review Manager 5 .0 software .Taking the fixed effects model or random effects model to merge OR values and corresponding 95% confidence intervals to assess Arg399Gln polymorphism and genetic sus‐ceptibility to nasopharyngeal .Results Compared 399Gln with 399Arg allele ,combined OR and 95% CI were 1 .14 (1 .04 - 1 .26) respectively ,and the results of heterogeneity test was I2 = 32% ,PHet = 0 .18 .Under the recessive and co‐dominant models ,combined OR and 95% CI were 1 .30(1 .04 - 1 .63) and 1 .37(1 .09 - 1 .72) respectively ,and with no significant heterogeneity was observed (I2 = 0 ,PHet = 1 .00) and (I2 = 0 ,PHet = 0 .96) .Conclusion XRCC1 gene Arg399Gln polymorphism is closely related to the genetic susceptibility of NPC ,399Gln allele may be a risk of genetic factors in NPC incidence in asians .